On the basis of long-term own researches and the analysis of the literary data are cited the data on specific structure of pulmonary nematodes of animals of Chechen Republic. Protostrongylidae is considered the most prevalent helminthosis of goats and sheep.

The specific structure of intestinal Protozoa at dogs, cats, rodents and primates of Moscow is investigated. The animals are infected by Cystoisospora ohioensis, C. canis, C. felis, C. rivolta, Eimeria sp., Sarcocystis sp., Giardia sp., oocysts subfamily Toxoplasmatinae, family Trichomonalidae, Blastocystis sp., Balantidium coli.

21 parasite species have been found in structure of variety of parasite species from hybrid sheep (mouflon × domestic sheep hybrids) contained within limited grazing territories of foothill zones of Armenia. These included 9 species of nematodes, 4 of cestodes, 3 of trematodes, 3 of ixodid ticks and larvae of nasopharyngeal gadfly Oestrus ovis and sheep ked Melophagus ovinus. An analysis of paths of circulation of larvae of some biohelminthes, particularly Dicrocoelidae and Protostrongylidae, realized through invertebrate intermediate hosts (land snails) have shown that mean infection of the latter varied from 2,5 to 8,0 %.

Variability of Dicrocoelium lanceatum size from cattle and wild hoofed animals depending on the host, the intensity of infection and environmental conditions is studied. The greatest degree of polymorphy in D. lanceatum is expressed from farm animals.

It is established that during fermentation of traditional food stuffs «kopal’chen» conditionally pathogenic microflora which is not rendering destructive influence on Trichinella nativa larva develops. Thus T. nativa larva keep viability and infective properties and can be a source of infection of indigenous population of Chukotka.

The results of helminthological studying of hunting grounds for interactions in a complex of earthworms and larval stages of Metastrongylus sp. are given.

Fauna molluscs – intermediate hosts and the degree of infection by Protostrongylus spp. larvae in comparative perspective (National Park «Losiniy ostrov», kostroma elk-farm and natural-historical reserve-spetsleskhoz «Gorki» is studied.

From HIV and hepatitis B and C risk groups 314 residents of the Republic of Altai were serologically examined for toxocarosis, HIV and hepatitis risk group includes medical workers, public servants, the unemployed, housewives and pensioners, 5,1 % of which (178 persons) had mixed infection of toxocarosis and hepatitis. 136 persons from the HIV risk group were not ill with toxocarosis.

The results of the research of the parameters of the proteins, carbohydrates, lipids and minerals metabolisms of chicks kittiwakes (Rissa tridactyla) are presented. The comparative analysis of the biochemical parameters of blood plasma noninfected birds and birds infected by Alcataenia larina, Tetrabothrius immerinus and Diphyllobothrium dendriticum are carried out. The most remarkable changes in metabolism note for chicks infected by A. larina and D. dendriticum. The peculiarities of the impact of species of the cestodes on metabolism of chicks are discussed.

The data on hematological, micromorphological and immunological reactions of obligate hosts (nestlings of herring gull) to cestode Diphyllobothrium dendriticum invasion in comparison with ones of unobligated hosts (syrian hamster, a cat) were analyzed. There were clear tendency to decreasing of hemoglobin level in blood of the infected herring gull’s nestlings. The tendency is partially compen-sated with the intensification of erythropoiesis in obligate hosts, and vice versa its depression in unobligated hosts. The cestode invasion activates Т-cell immune response and suppresses a B-cell response of unobligated hosts and activates lowly Т-and В-cell reactions of the obligate hosts.

Trichinellosis is accompanied by oxidative stress in cages of embryos of females of rats which is characterized by increase of level of diene conjugates on 63,12 % and malondialdehyde on 71,32 % and as decrease in activity of catalase on 46,62 %, superoxide dismutase on 36,47 %. In tissues of their embryos has shown decrease in the maintenance of vitamins and reduction of concentration of microelements. Therapy of experimental trichinellosis by one anthelmintic (albendazole or mebendazole) does not lead to normalisation of levels of vitamins and minerals in tissues of embryos. Application for complex therapy experimental trichinellosis of pregnant females of rats of a complex of vitamins of antioxidatic character with selenium will neutralize a disbalance of vitamins and minerals in tissues of em-bryos and negative action reactive oxygen species.

On pigs, experimentally infected by eggs Ascaris suum, Trichocephalus suis in a doze of respectively 500 and 200 eggs/kg of body weight, Oesophagostomum dentatum in a doze of 900 larva/kg and Strongyloides ransomi in a doze of 40 thousand of larva studied the dynamics cell factors of swine's organism immunobiological defense at mixed nematodosis comparatively with strongyloidosis monoinfection. It is established that the development of the pathological process at mixed nematodosis is accompanied by leucocytosis, eosinofilia, decreased number of erhythrocytes, lymphocytes and immunocompetent cells of T- and B-population, oppression of the helper and activation of the suppressor element of immune system, suppression of the receptor apparatus of the immunocompetent cells, decreased level of the mature T-lymphocytes and their functional activity.

It is offered sanitary-parasitological and veterinary-sanitary model of preventive maintenance of parasitic diseases of people and animals which approbation has resulted in the high effect expressing in reduction of number of cases of new infections in Bashkirija in 2,1 times.

Stomozan, ectocin-5, ratox or farmacidol-600 are recommended for control Gastrophilus spp. Farmacin intracutaneously are recommended for control Hypoderma spp. in cattle.

The results of improvement 7,5 % solutions of levamisol are stated at the main nematodosis of pigs. The drug in a doze of 7,5 mg/kg is effective, but toxic. To decrease its toxicity have added 1 % of crystal succinic acid that has allowed to increase efficiency on 2,8–8,6 % and to reduce toxicity.

Annual (during 7–12 years) using fenbendasol reduces its efficiency at strongylatosis of ruminants on 29,5% at the average, but in facilities where it is used for the first time its efficiency has formed at the average on 97,4 %.

It is developed new insektoakaricids preparations for control with ectoparasites (fleas, ixodoidea ticks). Insektoakaricids collars № 1, 2, 3, and also insektoakaricids collars (deltametrin) have shown high insektoakaricids action and long-term effect (from 4 till 6 weeks).

The influence of alvet-suspension on cats organism is defined and its efficiency at helminthoses are studied. Alvet-suspension doesn't render negative influence on animals organism and is highly effective against helminthosis. Hematological picture essentially does not change, insignificant fluctuations of activity of enzymes are marked. Efficiency at toxocarosis and toxascariosis has made 100 %, at uncinariosis – 95,7 and dipylidiosis – 94,1 %.

The influence of 1 % solution of cyfluthrin on reproductive function of rats is studied. The drug in a dose of 1/5 from LD50 during 10 weeks didn’t influence on fecundity, reproductive function and postnatal development of posterity.

The results indicate that the use of the drug flayblok residues of cyfluthrin in plasma, milk, organs and tissues are not found in any one of the selection date. The concentration of residual cyfluthrin below the detection limit of the method. Consequently, livestock products after treatment flayblok can be used without restriction.

Pharmacotoxicological properties of complex anthelmintic prazifen in the form of paste with fenbendazole and praziquantel are investigated. LD₅₀ of prazifen is 7500 mg/kg. Prazifen did not render negative influence on the skin of rats. The preparation has feebly marked cumulation.