Trials of solid dispersion of albendazole against helminthosis of young cattle

The purpose of the research is to evaluate the anthelmintic effect of solid dispersion (SD) of albendazole (ABZ) against the main helminthosis of young cattle.

Materials and methods. Experimental samples of SD ABZ were obtained by mechanochemical treatment of albendazole substance and polymer – polyvinylpyrrolidone in a roller mill LE-101 in the ratio of 1 : 9 at an energy intensity level of 1 g for 4 hours at a drum rotation speed of 60–70 rpm. The efficacy of SD ABZ was studied on 60 young cattle naturally infected with gastrointestinal strongylates. The animals were divided into 6 groups of 10 heads each. SD ABZ was administered orally to young animals of the 1st, 2nd and 3rd experimental groups in doses of 1.0; 2.0 and 3.0 mg/kg, respectively, of active substance (AS). Animals of the 4th and 5th groups received the basic drug – albendazole substance in doses of 2.0 and 7.5 mg/kg, respectively. Young animals of the 6th group did not receive the drugs and served as a control. The trials of SD ABZ were conducted on 28 heads of cattle against dictyocaulosis and on 30 heads of young cattle against monieziosis, which were divided into 3 groups of 8-10 heads each. SD ABZ was administered to the animals of the first groups at a dose of 2 mg/kg of AS. The animals of the second experimental groups received the ABZ substance at a dose of 2 mg/kg. The third groups served as control and did not receive treatment. The efficacy of the drugs was determined based on the results of coproovoscopic studies using the flotation method before and 18 days after treatment, and using the Berman method in case of dictyocaulosis.

Results and discussion. A high efficacy of the drug (98.7–99.3%) was established at a dose of 2.0 mg/kg of AS at titrating the therapeutic dose of SD ABZ against gastrointestinal strongylatosis of young cattle. We recommend this dose of the drug as a therapeutic one. The results of the SD ABZ study indicate 99.4% efficacy of the drug against monieziosis and 98.9% activity against dictyocaulosis of young cattle at the same dose. The basic drug – ABZ substance at a dose of 7.5 mg/ kg showed 97.8% effect against dictyocaulosis, 96.8% - against monieziosis and 86.2–89.8% effect against gastrointestinal strongylatosis of young cattle.

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