The efficacy of combined micronized Niclosamideand Albendazole-based dosage forms against bothriocephalosis of cyprinids
https://doi.org/10.31016/1998-8435-2022-16-4-450-456
Abstract
The purpose of the research is to develop and test new combined dosage forms against bothriocephalosis of cyprinids in the cage culture fishery.
Materials and methods. Combined micronized Niclosamide- and Albendazole-based dosage forms were developed; labscale batches of dosage forms of drugs and medicated feeds were developed with these drug forms; Bothriocephalus sp. infection rate in fish was determined during the growing period; and preliminary test effectiveness was confirmed for combined micronized niclosamide- and albendazole-based dosage forms against bothriocephalosis in cyprinids in the incubation shop of a cage culture fishery according to standard practices. The efficacy was assessed for combined micronized niclosamide- and albendazole-based dosage forms.
Results and discussion. The preliminary tests of combined micronized Albendazole- and Niclosamide-based dosage forms as part of medicated feeds showed 100% extense-effectiveness with 100% intense-effectiveness, and 60% extenseeffectiveness with 77.8% intense-effectiveness when administered once at a dose of 5% of the fish weight (doses for the active substance of 50 and 40 mg/kg, respectively).
Supporting agencies: This study was sponsored by the Russian Federation Ministry of Education and Science within the Program for Fundamental Scientific Research of the State Academies of Sciences, which forms the basis of State Task FGUG- 2022-0012 without additional funding attracted.
About the Authors
T. A. Vasilyeva
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Vasilyeva Tatyana A., Cand. Sc. Vet.
28, Bolshaya Cheremushkinskaya st., Moscow, 117218
D. P. Skachkov
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Skachkov Dmitry P., Cand. Sc. Vet.
28, Bolshaya Cheremushkinskaya st., Moscow, 117218
References
1. Bykhovskaya-Pavlovskaya I. E. Fish Parasites: Study Guide. L.: Nauka (Science), 1985; 118. (In Russ.)
2. Ershova T. A. Fenomix and Alben granules to treat cestode infections in fish of the family Cyprinidae and their pharmaco-toxicological characteristics: autoref. dis.... Cand. Sc. Vet. М., 2010; 22. (In Russ.)
3. Kalinnikova T. B., Gainutdinov M. Kh., Shagidullin R. R. Anthelmintic resistance: a problem and solution methods. Veterinarnyy vrach = Veterinarian. 2018; 5: 36-41. (In Russ.)
4. Collected instructions to control fish diseases. М., 1998; 310. (In Russ.)
5. Skachkov D. P., Pukhovsky Yu. A., Orlov V. T. Seasonal dynamics of Bothriocephalus sp. infection in cyprinids in the cage culture fishery under new keeping conditions. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2018; 12 (1): 45-51. (In Russ.) doi: 10.31016/1998-8435-2018-12-1-45-51
6. Skachkov D. P., Pukhovsky Yu. A., Orlov V. T., The use of a medicated feed mixture with Microsalum against bothriocephalosis of cyprinids in the cage culture fishery. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2018; 12 (2): 85- 90. (In Russ.) doi: 10.31016/1998-8435-2018-12-2-85-90
7. Skachkov D. P., Pukhovsky Y. A., Orlov V. T. Dynamics of infection of fry and fingerlings of carp with Bothryocephalus sp. in warm-water cage culture fishery at natural water temperature. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2019; 13 (4): 67–71. (In Russ.) doi: 10.31016/1998-8435-2019-13-4-67-71
8. Tarazevich E. Innovations in carp crosses with high commercial characteristics. Nauka i innovatsii = Science and Innovations. 2021; 8 (222): 41-44. (In Russ.)
9. Skachkov D. P., Safiullin R. T. Bothryocephaly of carp in a warm-water tank farm under natural conditions of fish keeping (dynamics of infection, therapeutic and preventive measures). IOP Conference Series: Earth and Environmental Science. 2021; 677 (5): 052064. doi: 10.1088/1755-1315/677/5/052064.
10. Skachkov D., Thakahova A. Bothriocephalus spp. infection of Cyprinidae: epizootology, clinical features and pathogenesis, diagnostics, therapeutic and prophylactic measures. AGROFOR International Journal. 2018; 3 (2): 91-96.
Review
For citations:
Vasilyeva T.A., Skachkov D.P. The efficacy of combined micronized Niclosamideand Albendazole-based dosage forms against bothriocephalosis of cyprinids. Russian Journal of Parasitology. 2022;16(4):450-456. (In Russ.) https://doi.org/10.31016/1998-8435-2022-16-4-450-456
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