Effect of therapeutic and prophylactic complex DLK (Dironet, Lactobifadol, Forage Keratin) on the intestinal microbiocenosis of the Blue Frost fox at toxascariosis

The purpose of the research is determining the effect of the therapeutic and prophylactic complex of Dironet, Lactobifadol and fodder Keratin (DLK) on the qualitative and quantitative composition of the intestinal microflora affected by toxascariosis in the Blue Frost fox.

Materials and methods. The research was carried out on the Fur Breeding Farm “Vyatka”, Slobodskoy District, the Kirov Region. The study objects were 24 female Blue Frost foxes culled from the breeding herd. To determine the quality of the skins obtained from the experimental animals, we sorted flint-dried skins.

Results and discussion. After the introduction of the therapeutic and preventive complex DLK into the diet of sick animals, the positive dynamics was observed in the quantitative and qualitative composition of intestinal microorganisms. In animals of the experimental groups that were administered DLK, the number of bifidus bacteria, lactic bacteria and fecal enterococci increased; there was a significant decrease or complete absence of pathogenic and conditionally pathogenic microorganisms, fusobacteria, streptococci, clostridia, typical lactose-negative and hemolytic Escherichia, aureus and saprophytic staphylococcus, common Proteus and fungi of the Candida genus. In animals infected by Toxascaris leonina that did not receive the complex therapy, a decrease in lactic acid bacteria and an increase in the content of pathogenic and commensal microorganisms were noted. Under the output of the fur production, the infected animals showed the lowest percentage of skins in terms of quality of 7.16%, which was 0.38% less in comparison with healthy foxes, and 0.51% less in comparison with treated Blue Frost foxes.

1. Arzhaev A. M. Possibilities of using BaksinumVet in fur farming. Veterinariya Kubani = Kuban Veterinary Medicine. 2008; 4: 13-14. (In Russ.)

2. Balakirev N. A, Yudin V. K. Guidelines for scientific and economic experiments on feeding fur-bearing animals. Moscow, 1994; 31. (In Russ.)

3. Balakirev N. A. Prospects for the industry development of cage fur farming in Russia. Veterinariya, zootekhniya i biotekhnologiya = Veterinary medicine, animal husbandry and biotechnology. 2018; 5: 54-57. (In Russ.)

4. Bespiatykh O. Yu., Balakirev A. N., Staroverova V. I., Maximov V. I., Berezina Yu. A., Pronina N. V., Sukhikh O. N., Kokorina A. E., Domskiy I.A. Effect of biologically active drugs on the metabolism of fur animals. Vestnik veterinarii = Bulletin of veterinary medicine. 2015; 72 (1): 48-51. (In Russ.)

5. Dorosheva A. M. Pharmacological correction of intestinal microflora with probiotic “Vetom 1.1” in polar foxes suffering from toxascariosis. Veterinariya = Veterinary medicine. 2009; 3: 36-40. (In Russ.)

6. Dorosheva A. M., Esaulova N. V., Akbayev M. Sh. Pathological changes in the small intestine of polar foxes suffering from toxascariosis. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2009; 3: 86-90. (DOI 10.31016/1998- 8435) (In Russ.)

7. Drozdova E. I., Loyenko N. N., Kholdkov S. V. Use of the Zoonorm probiotic for the treatment of polar fox puppies. Materialy dokladov 3 Mezhdunarodnogo simpoziuma "Fiziologicheskiye osnovy povysheniya produktivnosti mlekopitayushchikh, vvedennykh v zookul'turu" = Materials of the reports of the 3rd International Symposium "Physiological foundations of increasing the productivity of mammals introduced into zooculture". 2005; 49-50. (In Russ.)

8. Zhdanova O. B. Toxascaridosis in caged polar foxes, the influence of T. leonina on the occurrence of paraimmunological response. Sbornik nauchnykh trudov "Sovremennyye voprosy veterinarnoy meditsiny i biologii" = Collection of scientific papers "Modern issues of veterinary medicine and biology". 2000; 143. (In Russ.)

9. Konovalov A. P., Sapozhnikova A. I., Vasilevich F. I., Tsepilova I. I. The formation of the Blue Frost Fox hair with the use of the therapeutic and prophylactic anthelmintic complex DLK (Dironet, Lactobifadol, Forage Keratin). Veterinariya, zootekhniya i biotekhnologiya = Veterinary Medicine, Animal Science and Biotechnology. 2020; 9: 90–101. (In Russ.)

10. Podushkina M. A. Nitrogen balance of blue foxes suffering from toxascariosis. Sbornik nauchnykh trudov "Sovremennyye voprosy veterinarnoy meditsiny i biologii" = Collection of scientific papers "Modern issues of veterinary medicine and biology". 2000; 237. (In Russ.)

11. Sidorov M. A., Subbotin V. V. Normal microflora of animals and its correction with probiotics. Veterinariya = Veterinary medicine. 2001; 11: 33- 38. (In Russ.)

12. Skorodumov D. I., Subbotin V. V., Sidorov M. A., Kostenko T. S. Microbiological diagnostics of bacterial diseases of animals. Moscow: Izograf, 2005; 656. (In Russ.)

13. Stegniy B. T., Guzhvinskaya S. A. Prospects for the use of probiotics in animal husbandry. Veterinary medicine. 2005; 11: 10-11. (In Russ.)

14. GOST 7907-78. Rough skins of the blue fox. Technical conditions. Supersedes GOST 7907- 69; in force from 06/30/1979 until 07/31/2017. Moscow: Standards Publishing House, 1979; 6. (In Russ.)