Herbal Remedies with Anthelmintic Action. Myth or Reality
https://doi.org/10.31016/1998-8435-2019-13-3-82-87
Abstract
The purpose of the research is to study the anthelmintic action of an american drug intended for the treatment and prevention of helminthosis.
Materials and methods. A test of the effectiveness of an antiparasitic drug (USA), which includes: extracts of Jerusalem oak, citron seed, pumpkin seeds, male fern, thyme, wheatgrass, pomegranate bark, quartz mineral, table salt, etc. According to the instructions for use, the drug (series 61571-574-15) tested at a dose of 200 mg/kg three times a day for 7 days for the purpose of prevention and for 14 days for treatment. The phytopreparation is intended for the treatment of helminthosis in cats, dogs, rodents and birds. Anthelmintic has no contraindications and side effects, as well as age restrictions. In the experiment, 20 male rats weighing 200–220 g at the age of 3 months were used, spontaneously infected with Syphacia obvelata and Aspiculuris tetraptera (mixed infection). The diagnosis was made on the basis of a study of rat feces samples for the presence of nematode eggs according to the Darling method using a solution of zinc sulfate with a density of 1.32. The number of eggs was counted in 1 g of feces by the conventional method. Animals were divided into equivalent experimental and control groups of 10 animals each. The number of nematode eggs in 1 g of feces amounted to 56.32 specimens for the experimental group. eggs of S. obvelata, 44.44 eggs of A. tetraptera and for the control – 50.60 and 48.52 respectively.
Results and discussion. The results obtained indicate the absence of the anthelmintic effect of the american drug against S. obvelata and A. tetraptera in the recommended dose for 21 days. In addition, the animals were not only not released from the nematodes, but also reinfected, which allows us to conclude that there is no preventive effect.
About the Authors
N. B. Emelyanova
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"
Russian Federation
28, B. Cheremushkinskaya street, Moscow, 117218
Russian Federation
28, B. Cheremushkinskaya street, Moscow, 117218
O. P. Kurnosova
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"
Russian Federation
28, B. Cheremushkinskaya street, Moscow, 117218
Russian Federation
28, B. Cheremushkinskaya street, Moscow, 117218
M. V. Arisov
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"
Russian Federation
28, B. Cheremushkinskaya street, Moscow, 117218
Russian Federation
28, B. Cheremushkinskaya street, Moscow, 117218
References
1. Abdrashitova E. Kh., Zaitsev T. I., Braude N. A., Komarovskaya T. P., Novikova R. F., Poleschuk V. D., Kuhding E., Knopke K. et al. Quality Categories laboratory rodents for health reasons and their standardization. Proc. conf. "Laboratory livestock for biomedical and biotechnological research". M., 1990; 58–65. (In Rus.)
2. Aksenov V. I. General tasks of quality control of health of laboratory animals. Thes. conf. "Actual issues of standardization of laboratory animals for biomedical research". M., 1988; 1: 3–5. (In Rus.)
3. Arzybaev M. Development of anthelmintic agents from local raw materials and the study of their pharmacotoxicological properties: abstract. dis. ... Dr. Vet. sciences. M., 2005; 37. (In Rus.)
4. Bolotskikh L. A., Beskova T. B., Galakhova T. V., Zaitsev T. I. Gnobiotic method of obtaining and keeping pedigree nuclei of laboratory animals of SPF categories. Thes. conf. "Laboratory livestock for biomedical and biotechnological research". M., 1990; 46. (In Rus.)
5. Gadzhiev Ya. G., Eminov R. Sh. Prospects for the use of medicinal plants in the fight against animal helminthiasis. Studies in helminthology in Azerbaijan. 1984; 26–28, 85–92. (In Rus.)
6. Dushkin V. A. Laboratory livestock. M.: Rosselkhozizdat, 1980; 48. (In Rus.)
7. Zaitsev T. I. Quality control of laboratory animals. Thes. conf. "Actual issues of standardization of laboratory animals for biomedical research". M., 1988; 1: 19–21. (In Rus.)
8. Zapadnyuk I. P., Zapadnyuk V. I., Zakharia E. A. Laboratory animals: Breeding, keeping, use in experiment. Kiev: Vishcha school, 1974; 304. (In Rus.)
9. Kolotiy V. A. Comparative effectiveness of the acridine series (aminoacrychine, acrychin, aminoquinol, menacrine), filixan, extract of male fern in the experimental treatment of hymenolepidosis. Thes. and abstracts dokl. Scientific session Ukr. Institute of Advanced Medical Studies, dedicated. 20th anniversary of the Victory in World War II. Kharkov, 1965; 139-141. (In Rus.)
10. Krotov A. I. The search for new anthelminthic drugs of plant origin. Meditsinskaya parazitologiya i parazitarnyye bolezni = Medical parasitology and parasitic diseases. 1955; 24(2): 99–106. (In Rus.)
11. Krotov A. I. Experimental therapy of helminthosis. M.: Medgiz, 1961; 191. (In Rus.)
12. Krotov A. I. Experimental study of the effectiveness of combinations of aminoacrychine, yomezan and extract of male fern. Meditsinskaya parazitologiya i parazitarnyye bolezni = Medical parasitology and parasitic diseases. 1964; 33(2): 215–220. (In Rus.)
13. Laukaites V. L., Jonauskene I. D., Efimov V. I., Lugauskene A. Yu. Veterinary and sanitary monitoring of the quality of laboratory animals in the nursery of the Institute of Biochemistry of the Lithuanian SSR. Abstract. symp "Actual issues in the diagnosis of infectious diseases of the lab. animals, the development and production of modern diagnostic test systems". M., 1989; 69. (In Rus.)
14. Magerramov S. G. Helminthicidal pasture plants and toxicological assessment of cow parsnip: abstract. dis. ... cand. vet. sciences. M., 1991; 25. (In Rus.)
15. Poleshchuk V. D., Novikova R. F. Parasitic diseases of laboratory animals as biological models. Vestnik Akademii meditsinskikh nauk SSSR = Bulletin of the Academy of Medical Sciences of the USSR. 1983; 9: 72–75. (In Rus.)
16. Potemkina V. A. Test wormwood with moniesiosis of ruminants. Veterinarija = Veterinary medicine. 1956; 5: 34–35. (In Rus.)
17. Romanenko N. A. Sanitary helminthology. M.: Medicine, 1982; 176. (In Rus.)
18. Cherepanov A. A., Moskvin A. S., Kotelnikov G. A., Khrenov V. M. Atlas “Differential diagnosis of helminthosis by the morphological structure of eggs and larvae of the pathogen. M., 2001.
19. Schulz R. S. Therapy of helminthosis, the ways of its development and current state. Meditsinskaya parazitologiya i parazitarnyye bolezni = Medical parasitology and parasitic diseases.1933; 3: 117- 131. (In Rus.)
20. Brown H. W., Chan K. F., Ferrell B. D. A study of the Activity of Chemotherapeutic Agents on infections of Syphacia obvelata and Aspiculuris tetraptera. Exp. parasitol. 1954; 3(1): 45–51.
21. Chan K. F. Chemotherapeutic studies on Syphacia obvelata infection in mice. Amer. J. Hyg. 1952; 56(1): 22–30.
22. Hsieh K.-Y. N. The effect of the standard pinworm chemotherapeutic agents on the mouse pinworm Aspiculuris tetraptera. Amer. J. Hyg. 1952; 56(3): 287–293.
Review
For citations:
Emelyanova N.B., Kurnosova O.P., Arisov M.V. Herbal Remedies with Anthelmintic Action. Myth or Reality. Russian Journal of Parasitology. 2019;13(3):82-87. (In Russ.) https://doi.org/10.31016/1998-8435-2019-13-3-82-87
Views:
450
Email this article 