Toxicological assessment and inseсtoacaricid efficiency of the preparations «RolfСlub 3D Spray for Dogs» and «RolfСlub 3D Spray for Cats»

Abstract

The toxicological assessment is given and efficiency of complex preparations is studied. «RolfClub 3D spray for dogs» contains fipronil, D-cifenotrin, piriproxi-fen; «RolfСlub 3D spray for cats» – fipronil, etofenprox, piriproxifen. Preparations represent solution and are applied spot on as spray. Parameters of acute and skin toxicity of preparations for dogs and for cats are determined. LD50 at introduction in a stomach to mice made 5809±508,6 and 4295±607 mg/kg respectively, LD50 when drawing on skin to rats – more than 30000 mg/kg (the 4th class of danger). Preparations don't possess local irritating action. At application in twice and five time increased doses during 7 days have no negative impact on the general condi-tion of dogs and cats, their physiological status and behavior, don't change morpho-logical structure and biochemical indicators of blood and urine. Preparations pos-sess accurately expressed insektoakaricid activity on all stages of development of fleas, louses, ticks of the genius Sarcoptes and Demodex. Preparations don't cause side effects and complications.