Subacute toxicity of the injective anthelmintic drug Ritril

Abstract

Subacute toxicity of the injective anthelmintic drug Ritril containing in 1 ml 50 mg ricobendazole and 50 mg triclabendazole has been studied on rats. The med-ication applied by intramuscular injection at the doses of 40 and 100 mg/kg did not have any effect within 7 days on clinical status, consumption of food and water, hematological and biochemical values, mass coefficients of the organs and func-tional status of the examined animals. Verifiable changes of estimated values have been registered within 7 days by intramuscular injection of Ritril at a dose of 200 mg/kg. Change in relative liver and lungs weight, decrease of amount of erythro-cytes and hemoglobin in rat’s blood, verifiable change of liver values: total and direct bilirubin levels, amounts of aspartate aminotransferase and alanine ami-notransferase, and increase of blood urea concentration in rats are determined.