Effect of salivary glands extracts of Hyalomma asiaticum ticks on contractive activity of rat aortic smooth muscle cells
Abstract
Effect of ticks' salivary glands extract on contractive activity of rat aortic smooth muscle cells is studied. Aortic contractions have been induced using hyper- potassium solutions and noradrenaline. Registration of contractive activity of aorta was carried out in isometric regime and the changes were expressed as a percen- tage of the control values. It was determined that the salivary glands extract of ixo- did ticks Hyalomma asiaticum contains components that have a toxic effect on an- imals' body. Relaxant effect of salivary glands extract of Н. asiaticum is caused by its interaction with Са2+-transport systems of smooth muscle cells. Ticks salivary glands extract has an expressed hypotensive effect based on its ability to modify properties of transient receptor potential Са2+-channels of rat aortic smooth muscle cells.
About the Authors
S. H. Umrkulova
Institute of plants and animals genofond at Academy of Sciences of Uzbekistan
Tajikistan
junior research associate
Tajikistan
junior research associate
V. I. Golovanov
Institute of plants and animals genofond at Academy of Sciences of Uzbekistan
Tajikistan
PhD in biological sciences
Tajikistan
PhD in biological sciences
M. Sh. Bakiyeva
National University of Uzbekistan named after Mirzo Ulugbek
Tajikistan
lecturer
Tajikistan
lecturer
References
1. Balashov Ju.S. Parazito-hozjainnye otnoshenija chlenistonogih s na-zemnymi pozvonochnymi. -L.: Nauka, 1982. -S. 381-390.
2. Shuba M.F., Kochemasova N.G. Fiziologija sosudistyh gladkih myshc. -Kiev: Naukova dumka, 1988. -247 s.
3. Jenitsch T., Hubner S.A., Fuhrmann J. Ion channels: Function unraveled by dysfunction//Nature Cell Biology. -2004. -V. 6. P. 1039-1047.
4. Niemeyer B.A., Mery L., Zavar C., Suckov A. Ion channels in health and disease//EMBO Reports. -2001. -V. 2, № 7. -P. 568-573.
5. Vandier C., Jean-Yves Le Guennec., Bedfer G. What are the signaling pathways used by norepinephrine to contract the artery? A demonstration using guinea pig aortic ring segments // Adv. Physiol. Educ. - 2002. - V. 26. - P. 195- 203.
6. Webb R.C. Smooth muscle contraction and relaxation//Adv. Physiol. Edu. -2003. -V. 27. -P. 201-206.
Review
For citations:
Umrkulova S.H., Golovanov V.I., Bakiyeva M.Sh. Effect of salivary glands extracts of Hyalomma asiaticum ticks on contractive activity of rat aortic smooth muscle cells. Russian Journal of Parasitology. 2014;(2):15-17. (In Russ.)
Views:
205
Email this article 