EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP
Abstract
Effectiveness of a supramolecular nanotech-based Albendazole – Fenbendazole complex has been tested using the Drug Delivery System. Tests for efficacy of new drugs Albendazole and Fenbendazole were conducted on 37 sheep spontaneously infected with Nematodirus sp. and other gastrointestinal strongylates in agricultural farm «Leninsky Put’» located in Pestravsky district of Samara region. The supra-molecular Albendazole – Arabinogalactan complex at a dose of 1,0 mg/kg of active ingredient and the base Albendazole at a dose of 10 mg/kg have shown a 100 % effectiveness. Albendazole – Chitosan complex has shown a 87,5 % extenseffectiveness and a 98,4 % reduction in number of nematode eggs in feces. The effectiveness of supramolecular Fenbendazole – polymer complex was lower.
About the Authors
A. I. Varlamova
All-Russian Scientific Research Institute of fundamental and applied parasitology of animals and plants
117218, Moscow, B. Cheremushkinskaya str., 28
Russian Federation
Russian Federation
V. A. Dolgoshev
Samara Research Veterinary Station
Russian Federation
Russian Federation
K. M. Sadov
Samara Research Veterinary Station
Russian Federation
Russian Federation
E. E. Belova
All-Russian Scientific Research Institute of fundamental and applied parasitology of animals and plants
117218, Moscow, B. Cheremushkinskaya str., 28
Russian Federation
Russian Federation
I. I. Glamazdin
All-Russian Scientific Research Institute of fundamental and applied parasitology of animals and plants
117218, Moscow, B. Cheremushkinskaya str., 28
Russian Federation
Russian Federation
S. S. Halikov
A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS)
119991, Moscow, Vavilov str., 28
Russian Federation
Russian Federation
Yu. S. Chistyachenko
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of RAS 630128, Novosibirsk, 18, Kutateladze str.
Russian Federation
Russian Federation
A. V. Dushkin
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of RAS 630128, Novosibirsk, 18, Kutateladze str.
Russian Federation
Russian Federation
S. D. Durdusov
Moscow Academy of Economics and Law, Kalmyk Branch Elista, 5 Gorodovokov str.
Russian Federation
Russian Federation
I. A. Arkhipov
All-Russian Scientific Research Institute of fundamental and applied parasitology of animals and plants
117218, Moscow, B. Cheremushkinskaya str., 28
Russian Federation
Russian Federation
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Review
For citations:
Varlamova A.I., Dolgoshev V.A., Sadov K.M., Belova E.E., Glamazdin I.I., Halikov S.S., Chistyachenko Yu.S., Dushkin A.V., Durdusov S.D., Arkhipov I.A. EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP. Russian Journal of Parasitology. 2015;(1):71-74. (In Russ.)
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