Efficacy of microfilaricidal therapy in dogs and cats in endemic areas to dirofilariosis
https://doi.org/10.31016/1998-8435-2025-19-3-343-352
Abstract
The purpose of the research is to study the efficacy of drugs in a solution formulation for external use to prevent dirofilariosis in dogs and cats.
Materials and methods. The VNIIP – FSC VIEV developed two drugs based on imidacloprid, praziquantel, moxidectin, and pyriproxyfen to treat and prevent ecto- and endoparasitosis in dogs and cats. The studies were conducted on 12 cats and 12 dogs of different sexes, age groups and body weights naturally infected with microfilaria of Dirofilaria spp. in Moscow and the Moscow Region during an active mosquito flight from May to September 2021–2022. The animals were treated with the drugs once, on the skin. To detect microfilaria in the blood, the microscopic slide test and the V. B. Yastreb concentration method (2004) were used. The drug prophylactic efficacy was recorded using the “control test” with the calculation of the average number of parasites detected.
Results and discussion. It was found that the studied drugs showed high prophylactic efficacy against microfilaria of Dirofilaria spp. that circulated in the blood of the dogs and cats on day 60 of the study. No side effects or complications were observed when the drugs were used in the animals.
Keywords
About the Authors
I. P. Belykh
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Belykh Irina P., Candidate of Biological Sciences, Senior Researcher
Researcher ID: U-5007-2018
Scopus ID: 57218097154
Moscow
G. B. Arisova
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Arisova Gulnara B., Candidate of Veterinary Sciences, Leading Researcher of the Laboratory of Experimental Therapy
Researcher ID: U-5425-2018
Scopus ID: 57207925459
Moscow
D. S. Poselov
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Poselov Dmitry S., Candidate of Veterinary Sciences, Senior Researcher
Researcher ID: U-6241-2018
Moscow
A. A. Stepanov
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Stepanov Alexey A., Candidate of Veterinary Sciences, Senior Researcher
Researcher ID: U-8135-2018
Moscow
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For citations:
Belykh I.P., Arisova G.B., Poselov D.S., Stepanov A.A. Efficacy of microfilaricidal therapy in dogs and cats in endemic areas to dirofilariosis. Russian Journal of Parasitology. 2025;19(3):343-352. (In Russ.) https://doi.org/10.31016/1998-8435-2025-19-3-343-352
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