Morphological justification of organ-preserving methods of surgical treatment of patients with liver echinococcosis
A. V. Shabunin,
A. A. Karpov,
V. V. Bedin,
M. M. Tavobilov,
S. S. Lebedev,
I. O. Tin’kova,
D. S. Ozerova,
M. N. Aladin,
F. F. Alieva,
G. S. Mikhailyantc,
A. Yu. Lukin https://doi.org/10.31016/1998-8435-2022-16-4-494-503
Abstract
The purpose of the research is the study of the morphological structure of echinococcal cysts to assess the possibility of using organ-preserving methods of surgical treatment.
Materials and methods. A clinical, instrumental, and morphological fundamental study was performed in the Surgical Clinic of the Botkin Hospital when radiation and morphological data in addition to clinical data were studied for 28 patients who underwent surgical treatment for liver echinococcosis. Excised gross specimens were examined to study the capsule structure, and the penetration of germinal elements of the cysts through membranes of the parasite (64 successively excised primary operated echinococcal cysts).
Results and discussion. The fibrous capsule of the echinococcal cyst is a good barrier against Protoscolexes penetrating into the liver tissue. None of the 64 specimens studied in detail was found to have germinal elements of any echinococcal cyst penetrating through its fibrous capsule. The morphological justification of organ-preserving methods in the treatment of patients with liver echinococcosis allows a conclusion that these interventions are safe and radical.
About the Authors
A. V. Shabunin
Botkin Hospital; Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Shabunin Alexey V., Dr. Sc. Med., Professor
5, 2nd Botkinsky proezd, 125284, Moscow
A. A. Karpov
Botkin Hospital
Russian Federation
Russian Federation
Karpov Alexey A., Cand. Sc. Med.
5, 2nd Botkinsky proezd, 125284, Moscow
V. V. Bedin
Botkin Hospital; Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Bedin Vladimir V., Dr. Sc. Med.
5, 2nd Botkinsky proezd, 125284, Moscow
M. M. Tavobilov
Botkin Hospital; Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Tavobilov Mikhail M., Dr. Sc. Med.
5, 2nd Botkinsky proezd, 125284, Moscow
S. S. Lebedev
Botkin Hospital; Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Lebedev Sergey S., Cand. Sc. Med.
5, 2nd Botkinsky proezd, 125284, Moscow
I. O. Tin’kova
Botkin Hospital
Russian Federation
Russian Federation
Tin’kova Irina O., Cand. Sc. Med.
5, 2nd Botkinsky proezd, 125284, Moscow
D. S. Ozerova
Botkin Hospital; Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Ozerova Daria S., Operating Surgeon
5, 2nd Botkinsky proezd, 125284, Moscow
M. N. Aladin
Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Aladin Mark N., Resident
2/1 (1) Barrikadnaya Str., 123995, Moscow
F. F. Alieva
Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Alieva Fariza F., Resident
2/1 (1) Barrikadnaya Str., 123995, Moscow
G. S. Mikhailyantc
Botkin Hospital; Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Mikhailyantc Georgy S., Dr. Sc. Med., Professor
5, 2nd Botkinsky proezd, 125284, Moscow
A. Yu. Lukin
Botkin Hospital; Russian Medical Academy of Postgraduate Study, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Lukin Andrey Yu., Dr. Sc. Med., Professor
5, 2nd Botkinsky proezd, 125284, Moscow
References
1. Pautov F. N. Characteristics of unilocular and multilocular echinococcus in Omsk: autoref. dis. … Cand. Sc. Med. Omsk, 1969; 18. (In Russ.)
2. Siria T. I. On the penetration of scolexes through the fibrous capsule: autoref. dis. … Cand. Sc. Med. Tbilisi, 1950; 13. (In Russ.)
3. Shabunin A. V., Tavobilov M. M., Karpov A. A. Hepatic echinococcosis: evolution of surgical treatment. Khirurgiya. Zhurnal im. N. I. Pirogova = Surgery. Journal named after N. I. Pirogov. 2021; 5: 95-103. (In Russ.) doi10.17116/hirurgia202105195
4. Akbulut S., Sahin T. T. Comment on the management of liver hydatid cyst with cystobiliary communication and acute cholangitis: a 27-year experience. Eur. J. Trauma Emerg. Surg. 2021; 47: 617–618. https://doi.org/10.1007/s00068-021-01608-0
5. Baimakhanov Z., Kaniyev S., Serikuly E., Doskhanov M., Askeyev B., Baiguissova D., Skakbayev A., Sadykov C., Barlybay R., Seisembayev M., Baimakhanov B. Radical versus conservative surgical management for liver hydatid cysts: A single-center prospective cohort study. JGH Open. 2021; 5 (10): 1179-1182. https://doi.org/10.1002/jgh3.12649
6. Barth T. F. E., Casulli A. Morphological characteristics of alveolar and cystic echinococcosis lesions human liver and bone. Pathogens. 2021; 10 (10): 1326. https://doi.org/10.3390/pathogens10101326
7. Beigh A. B., Darzi M. M., Bashir S. et al. Gross and histopathological alterations associated with cystic echinococcosis in small ruminants. J. Parasit. Dis. 2017; 41. 1028–1033. https://doi.org/10.1007/s12639-017-0929-z
8. Beigh A. B., Darzi M. M., Bashir S., Shah A., Shah S. A. The pathology of cystic echinococcosis and structural details of hydatid cyst and protoscolex. Indian J. Vet. Pathol. 2018; 42 (1): 8-14. doi: 10.5958/0973-970X.2018.00002.0
9. Chaouch M. A., Dougaz M. W., Cherni S. et al. Daughter cyst sign in liver hydatid cyst. J. Parasit. Dis. 2019; 43. 737–738. https://doi.org/10.1007/s12639-019-01140-4
10. Collado Aliaga J., Romero-Alegría Á., Alonso-Sardón M. et al. Portal Hypertension as a Complication of Cystic Echinococcosis: A 20-Year Cohort Analysis. The American Journal of Tropical Medicine and Hygiene. 2021;105 (3): 692-697. doi: 10.4269/ajtmh.21-0274. PMID: 34280145.
11. Guerret S., Vuitton D., Liance M. et al. Echinococcus multilocularis: relationship between susceptibility/ resistance and liver fibrogenesis in experimental mice. Parasit. Res. 1998; 84. 657–667. https://doi.org/10.1007/s004360050466
12. Jaén-Torrejimeno I., Latorre-Fragua R., López- Guerra D. et al. Jaundice as a clinical presentation in liver hydatidosis increases the risk of postoperative biliary fistula. Langenbecks Arch. Surg. 2021; 406. 1139–1147. https://doi.org/10.1007/s00423-020-02070-z
13. Khan S. N., Ali R., Khan S. et al. Cystic echinococcosis: an emerging zoonosis in southern regions of Khyber Pakhtunkhwa, Pakistan. BMC Vet. Res. 2021; 17. 139 (2021). https://doi.org/10.1186/s12917-021-02830-z
14. Li Y. P., Ma Z. G., Tuxun T. et al. The application of laparoscopy combined with indocyanine green fluorescence imaging technique for hepatic cystic echinococcosis. BMC Surg. 2020; 20. 249. https:// doi.org/10.1186/s12893-020-00911-8
15. Mönnink G. L. E., Stijnis C., van Delden O. M. et al. Percutaneous Versus Surgical Interventions for Hepatic Cystic Echinococcosis: A Systematic Review and Meta-Analysis. Cardiovasc. Intervent. Radiol. 2021; 44. 1689–1696. https://doi.org/10.1007/s00270-021-02911-4
16. Torgerson P. R., Macpherson C. N. L. The socioeconomic burden of parasitic zoonoses: global trends. Vet. Parasitol. 2011; 182. 79-95
Review
For citations:
Shabunin A.V., Karpov A.A., Bedin V.V., Tavobilov M.M., Lebedev S.S., Tin’kova I.O., Ozerova D.S., Aladin M.N., Alieva F.F., Mikhailyantc G.S., Lukin A.Yu. Morphological justification of organ-preserving methods of surgical treatment of patients with liver echinococcosis. Russian Journal of Parasitology. 2022;16(4):494-503. (In Russ.) https://doi.org/10.31016/1998-8435-2022-16-4-494-503
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