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Methodology for application of supramolecular fenbendazole against helminthosis of ruminants

https://doi.org/10.31016/1998-8435-2021-15-4-57-60

Abstract

The purpose of the research is developing a methodology for application of the supramolecular complex of fenbendazole (SMCF) against helminthosis in ruminants.

The SMCF was obtained by the method of mechanochemical technology with polyvinylpyrrolidone (PVP) in a ratio of 1 : 10 in a balling drum. The drug was produced in plastic cans of 2, 4 and 8 kg and stored in its original packaging in dry, nonresidential area. The SMCF was used against gastrointestinal strongylatosis, dictyocaulosis and monieziosis of sheep and goats at a dose of 20 mg/kg (2 mg/kg for the active substance). The methodology provides a brief chemical characteristic of the SMCF, summarizes its mode of action, and describes toxicological properties, which gives an idea of the drug in general. The procedure is described for preparing the drug for use on animals, both individually and in a group. Reasoned recommendations are given on the timing for animal slaughter, and the use of milk after treating cows.

About the Author

A. I. Varlamova
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”
Russian Federation

Anastasiya I. Varlamova, Candidate of Veterinary Sciences

117218, Moscow, B. Cheremushkinskaya st., 28



References

1. Arkhipov I. A. Anthelmintics: pharmacology and application. M., 2009; 409. (In Russ.)

2. Arkhipov I. A., Khalikov S. S., Dushkin A. V., Varlamova A. I., Musayev M. B., Polyakov N. E., Chistyachenko Yu. S., Sadov K. M., Khalikov M. S. Supramolecular complexes of anthelmintic benzimidazole drugs. Production and properties. M.: New authors, 2017; 91. (In Russ.)

3. Varlamova A. I., Limova Yu. V., Sadov K. M., Sadova A. K., Belova E. E., Radionov A. V., Khalikov S. S., Chistyachenko Yu. S., Dushkin A. V., Skira V. N., Arkhipov I. A. The efficacy of the supramolecular complex of fenbendazole against nematodiases of sheep. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2016; 35 (1): 76–81. (In Russ.)

4. Varlamova A. I. Anthelmintic efficacy of the supramolecular complex of fenbendazole against nematodiases of young cattle. Veterinariya = Veterinary Medicine. 2017; 1: 32–35. (In Russ.)

5. Varlamova A. I., Arkhipov I. A. Comparative acute toxicity of the supramolecular complex of fenbendazole using different polymers for targeted delivery. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2020; 14 (2): 83-87. (In Russ.)

6. Safiullin R. T. Distribution and economic damage from the main helminthiases of ruminants. Veterinariya = Veterinary Medicine. 1997; 6: 28-32. (In Russ.)


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For citations:


Varlamova A.I. Methodology for application of supramolecular fenbendazole against helminthosis of ruminants. Russian Journal of Parasitology. 2021;15(4):57-60. (In Russ.) https://doi.org/10.31016/1998-8435-2021-15-4-57-60

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ISSN 1998-8435 (Print)
ISSN 2541-7843 (Online)