Study of the pharmacokinetics of moxidectin in the body of carnivores using an antiparasitic drug in the form of tablets

Abstract

The purpose of the research is studying the pharmacokinetics of moxidectin in the blood serum of cats and dogs after a single administration of antiparasitic drug «Neoterika Protecto tablets».

Materials and methods. The studies were performed at the premises of the Kurilovo experimental farm of the VNIIP – FSC VIEV on clinically healthy animals of both sexes aged 1-4 years, namely, 6 cats weighing 1.5–2.0 kg and 6 dogs weighing 10.3–13.8 kg. The drug was administered once orally at the rate of 1.5 mg of moxidectin per 1 kg of body weight. Blood samples were taken in the amount of 2 ml from cats and 4–5 ml from dogs before the drug and after 3, 6, 12, 24 hours, and 3, 6, 10, 20, 45, 60, 75, and 90 days. The study used the high-performance liquid chromatography. We determined the moxidectin content in the blood serum. Based on the results, we calculated the pharmacokinetic parameters of the active substance in the body of cats and dogs.

Results and discussion. It was found that the active substance concentration within 3 hours after a single use of the moxidectin-based drug in the form of tablets reached a level of 134.8–498.0 ng/ml in cats and 479.08–1459.4 ng/ml in dogs; moxidectin was present in the bloodstream of cats and dogs for 90 days. Thus, a single administration of the drug at the recommended therapeutic dose of 1.5 mg/kg allows for the therapeutic moxidectin concentration to be maintained for 90 days.