Аntiparasitic complex of Ivermectin for treatment of herd horses at gastrointestinal Nematodosis

The purpose of the research is evaluating the efficacy of the antiparasitic complex based on ivermectin obtained by mechanochemical technology against gastrointestinal nematodosis of herd horses.

Materials and methods. The efficacy of the ivermectin-based antiparasitic complex was tested in December-February 2019 in the Southern Federal District of the Chechen Republic in a private farm on 22 stabled foals aged over one year. To diagnose gastrointestinal parascaridosis and strongylatosis, feces of foals were examined using the Fulleborn’s method. Helminth eggs in 1 g of feces were counted in a counting chamber of the All-Russian Scientific Research Institute of Helminthology. In order to diagnose oxyurosis, pieces of transparent adhesive tape with prints from perianal folds were transferred to a glass slide and examined for Oxyuris spp. eggs. The antiparasitic complex of ivermectin 2% was administered in a mixture with food at a dose of 0.1 mg/kg by the drug (0.2 mg/kg by the active substance). After a preliminary test of the ivermectin complex efficacy, the therapeutic dose of the drug was titrated on 46 adult horses (aged 2–4 years) from the same private entrepreneur. The horses spontaneously infected with Strongylata, Parascarids and Oxyurises were divided into 5 groups according to the analogue principle. For animals of groups 1, 2, and 3, the drug was administered at a doses of 0.1, 0.15 and 0.2 mg/kg by the AS respectively. The horses of groups 4 and 5 were given the substance of ivermectin at a doses of 0.1 and 0.2 mg/kg by the AS, mixed with combined feed individually. The efficacy of the supramolecular complex of ivermectin was recorded according to the data of coproovoscopic studies using the critical test method according to the Guidelines approved by the World Association for the Advancement of Veterinary Parasitology (1995).

Results and discussion. The rate of infection of the foals with Strongylata, Parascarids and Oxyurises was 100, 40 and 55% respectively as resulted from the coproovoscopic studies. The dissections showed that the intensity of infection with Strongylata was equal to 477.4±23.87 individuals per animal, Parascarids 447.1±55.89, and Oxyurises 22.2±2.02. The 100 % efficacy was determined for the antiparasitic complex of ivermectin at a dose of 0.1 mg/kg by the drug (0.2 mg/kg by the AS) against the main gastrointestinal nematodes. The substance of ivermectin at a dose of 0.2 mg/kg showed 87.5% efficacy against Strongylata and Parascarids, and at a dose of 0.1 mg/kg, it showed a lack of efficacy (50.0 and 25.0% respectively). We recognized the dose of 0.15 mg/kg by the AS of the supramolecular complex of ivermectin with one-time individual use in a mixture with food as therapeutic. 

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