Comparative acute toxicity of supramolecular complexes of Fenbendazole with Different Polymers used for targeted Delivery
https://doi.org/10.31016/1998-8435-2020-14-2-83-87
Abstract
The purpose of the research is studying acute toxicity of supramolecular complexes of fenbendazole with different polymers obtained by mechanochemical technology as compared to the substance of the drug when administered to the stomach of white mice.
Materials and methods. The acute toxicity parameters of supramolecular complexes of fenbendazole (SMCF) with different polymers were studied under the “Guide to experimental (preclinical) study of new pharmacological substances” and other rules. The drugs were administered once to the stomach of white mice of both genders with a body weight of 16–18 g at doses of 7,000, 10,000, 15,000 and 20,000 mg/kg by the drug. Each dose was tested on 10 white mice. For 14 days, we observed the general condition and behavior of animals, symptoms of intoxication and possible death. Postmortem examination was performed for the dead animals. Acute toxicity was determined by Litchfield and Wilcoxon (M. D. Belenky, 1963).
Results and discussion. LD50 of the SMCF and the major drug of fenbendazole could not be established due to low toxicity. LD50 of the SMCF administered to the stomach of white mice was 20 000 mg/kg.
About the Authors
A. I. Varlamova
1 All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"; Moscow State Academy of Veterinary Medicine and Biotechnology named after K. I. Skryabin
Russian Federation
28, B. Cheremushkinskaya st., Moscow, Russia, 117218
Russian Federation
28, B. Cheremushkinskaya st., Moscow, Russia, 117218
I. A. Arkhipov
Moscow State Academy of Veterinary Medicine and Biotechnology named after K. I. Skryabin
Russian Federation
23 Akademik Skryabin st., Moscow
Russian Federation
23 Akademik Skryabin st., Moscow
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Review
For citations:
Varlamova A.I., Arkhipov I.A. Comparative acute toxicity of supramolecular complexes of Fenbendazole with Different Polymers used for targeted Delivery. Russian Journal of Parasitology. 2020;14(2):83-87. (In Russ.) https://doi.org/10.31016/1998-8435-2020-14-2-83-87
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