Evaluation of Local Irritant Action of Complex Insectoacaricide Drug "Rolfclub 3D Shampoo” on Rats’ Skin and Guinea Pigs’ Mucous Membranes of the Eyes
https://doi.org/10.31016/1998-8435-2019-13-1-47-51
Abstract
The purpose of the research is to study of local irritant action of complex insectoacaricide drug "RolfClub 3D shampoo” on rats’ skin and guinea pigs’ mucous membranes of the eyes.
Materials and methods. Local irritant action of complex insectoacaricide drug "RolfClub 3D shampoo” was evaluated in the experiment on determination of acute skin toxicity of rats on the thickness of skin fold. Only animals with healthy skin, which was kept on standard dietary and which has undergone 7 days absolute quarantine before experiment, were used. Studies on determination of local irritant action of aqueous solution of active ingredients combination of shampoo on conjunctiva of guinea pigs’ eyes were conducted on adult albino guinea pigs with body weight of 250–300 g. Each animal's eye condition was visually evaluated for determination of expressed injuries not later than 24 hours.
Results and discussion. Symptoms of irritant action were not noticed in the case of exposure of aqueous solution of active ingredients combination of shampoo on rats’ skin. After application skin areas was not differ from control skin areas. Redness of whole conjunctiva and sclera was noted in the case of application of solution on mucous membranes of the eyes. This event disappeared in 24 hours. Condition of animals’ mucous membranes of the eyes pretreated water was within the physiological range. Aqueous solution of active ingredients combination has mild effect on mucous membranes of the eyes; recovery up to normal range carries within 24 hours.
About the Authors
M. V. Arisov
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"
Russian Federation
Russian Federation
Mikhail V. Arisov
28, B. Cheremushkinskaya Street, Moscow, 117218
A. A. Stepanov
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"
Russian Federation
Russian Federation
Aleksey A. Stepanov
28, B. Cheremushkinskaya Street, Moscow, 117218
G. B. Arisova
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"
Russian Federation
Russian Federation
Gulnara B. Arisova
28, B. Cheremushkinskaya Street, Moscow, 117218
References
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Review
For citations:
Arisov M.V., Stepanov A.A., Arisova G.B. Evaluation of Local Irritant Action of Complex Insectoacaricide Drug "Rolfclub 3D Shampoo” on Rats’ Skin and Guinea Pigs’ Mucous Membranes of the Eyes. Russian Journal of Parasitology. 2019;13(1):47-51. (In Russ.) https://doi.org/10.31016/1998-8435-2019-13-1-47-51
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