Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats
https://doi.org/10.31016/1998-8435-2019-13-4-77-82
Abstract
The purpose of the research is to assess the acute oral toxicity of the drug Altrik-Extra in mice and rats, to determine its hazard class depending on the degree of exposure to animals.
Materials and methods. White outbred mice and rats were used in the experiment. In the study of acute oral toxicity, conventional techniques were used.
Results and discussion. Average lethal doses of LD50 were established when administered orally to laboratory animals. For mice, LD50 was more than 5986 mg/kg. Thus, according to the generally accepted hygienic classification (GOST 12.1.007-76), Altrick- Extra belongs to the 4th hazard class (low-hazard substances). In the study of acute oral toxicity in rats, LD50 was 3 103.1±748.5 mg/kg (confidence interval boundaries 2 354.6÷3 851.5 mg/kg). Therefore, in accordance with GOST 12.1.007-76, the studied drug belongs to the 3rd class of danger (moderately dangerous substances).
About the Authors
E. V. Lagereva
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"
Russian Federation
Russian Federation
28, B. Cheremushkinskaya street, Moscow, 117218
V. E. Abramov
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants – a branch of Federal State Budgetary Institution of Science "Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of the Russian Academy of Sciences"
Russian Federation
Russian Federation
28, B. Cheremushkinskaya street, Moscow, 117218
References
1. Belenky M. L. Elements of a quantitative assessment of the pharmacological effect: Monograph. Leningrad: Medgiz, 1963; 146. (In Russ.)
2. Harmful substances. Classification and general safety requirements: GOST 12.1.007-76. Enter. 1977-01-01. M.: Standartinform, 2007; 7.
3. Emelyanova N. B., Abramov V. E., Glazyev E. N., Balyshev A. V. Acute oral and subacute toxicity of the drug Trisulfone Suspension. Mezhdunarodnyy vestnik veterinarii = International Veterinary Newsletter. 2013; 2: 34–37. (In Russ.)
4. Karkishchenko N. N. Guide for laboratory animals and alternative models in biomedical technologies. M., 2010; 344. (In Russ.)
5. Guidance on the experimental (preclinical) study of new pharmacological substances. Ed. Corresponding Member of RAMS, prof. R. U. Khabriev. M.: Medicine, 2005; 832.
6. Guidelines for preclinical studies of drugs. Part One. Ed. A. N. Mironov. M.: Grif and K, 2012; 944.
7. Guidelines for the maintenance and care of laboratory animals. Rules for the maintenance and care of laboratory rodents and rabbits: GOST 33216-2014. Enter. for the first time. M.: Standartinform, 2016; 16.
8. Guidelines for the maintenance and care of laboratory animals. Rules for equipment of premises and organization of procedures: GOST 33215-2014. Enter. for the first time. M.: Standartinform, 2016; 19.
9. SP 2.2.1.3218-14 "Sanitary and epidemiological requirements for the design, equipment and maintenance of experimental biological clinics (vivariums)."
10. Venkatesan P. S., Deecaraman M., Vijayalakshmi M., Sakthivelan S. M. Sub-acute Toxicity Studies of Acetaminophen in Sprague Dawley Rats. Biol. Pharm. Bull. 2014; 37 (7): 1184–1190.
Review
For citations:
Lagereva E.V., Abramov V.E. Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats. Russian Journal of Parasitology. 2019;13(4):77-82. (In Russ.) https://doi.org/10.31016/1998-8435-2019-13-4-77-82
Views:
337
Email this article 