The effectiveness of supramolecular complxes of triclabendazole with polymers against Fasciola

Abstract

With the usuing of mechanochemical nanotechnology in the mills of shock-attrition type with adjustable energy densities, developed 10 innovative drugs in the form of supramolecular complexes on the basis triclabendazole with various water-soluble polymers without participation of the liquid phase in one stage. They are fine dry water-soluble powders with a particle size of 1-10 microns. All tested supramolecular complexes of triclabendazole against sexually Mature at 5, and immature Fasciala 10 times more effective than the drug substance of Tticlabendazole. For technical and economic reasons the most optimal product for introduction into veterinary practice is the complex Tticlabendazole, with a water-soluble polysaccharide arabinogalactan, extracted from larch, environmentally and safe product that is widely used in medicine. It is known that water-insoluble anthelmintic, applied to animals orally, to 70.0% excreted into the environment unchanged in the faeces, contaminating the environment. Water-soluble supramolecular complexe Tticlabendazole used in a reduced dose, soaked in blood, provide a high biological availability. In the future, they are broken down and eliminated in the urine from the body in miniscule amounts, without polluting the environment. These positive signs supramolecular complex compared with the substance triclabendazole anthelmintic and provide high economic efficiency and safety.