CUMULATIVE PROPERTIES OF NEW DOMESTIC ANTHELMINTIC PREPARATION NADINATE
Abstract
Cumulative properties of a new domestic anthelmintic nadinate as well as its effect on cestodes and nematodes have been studied. The experiments have been performed in white mongrel male rats which were injected with a nadinate suspension prepared on the base of 1 % starch mucilage. Nadinat appointed in the first four days in a dose of 500,7 mg/kg and then every four days 1,5 times to 50 % death of animals. By injection of nadinate into the rats stomachs the cumulative coefficient was 3,2 over 28 days what is the evidence of absence of cumulative properties.
About the Authors
S. A. KOZLOV
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K. I. Skryabin, Moscow
Russian Federation
Russian Federation
postgraduate
117218, 28 Bol. Cheremushkinskaya str.
M. B. MUSAEV
All-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K. I. Skryabin, Moscow
Russian Federation
Russian Federation
research advisor
doctor of veterinary sciences
117218, 28 Bol. Cheremushkinskaya str.
References
1. Gosudarstvennaja farmakopeja. T. H1, Vyp.2. – M., 1968 – S. 182.
2. Kozlov, S. A. Ostraja toksichnost' nadinata / S. A. Kozlov, M. B. Musaev i dr. // Ros. parazitol. zhurnal. – 2013. – № 2. – S. 120–122.
3. Kozlov, S. A. Antigel'mintnaja jeffektivnost' i terapevticheskie dozy innovacionnogo otechestvennogo antigel'mintika nadinat pri moniezioze ovec / S. A. Kozlov, M. B. Musaev, F. S. Mihajlicyn, A. Ju. Malahova, D. P. Sevbo // Med. parazitol. i parazit. bol. – 2014. – Vyp. 36, № 2. – S. 47–49.
4. Metodicheskie ukazanija po gigienicheskoj ocenke novyh pesticidov. – Kiev, 1988. – S. 32–35.
5. Mihajlicyn, F. S. Poluchenie opytnogo obrazca antigel'mintika nadinata (MST-02) i ocenka ego lechebnoj jeffektivnosti pri moniezioze i strongiljatozah ovec / F. S. Mihajlicyn, D. P. Sevbo, S. N. Trusov i dr. // Med. parazitol. i parazit. bol. – 2011. – № 2. – S. 41.
6. Pravila laboratornoj praktiki v Rossijskoj Federacii: [Prikaz ministerstva zdravoohranenija RF, № 708n ot 23.08.2010 g.].
7. Rukovodstvo po jeksperimental'nomu (doklinicheskomu) izucheniju novyh farmakologicheskih veshhestv / pod red. R. U. Habrieva. – Moskva: Medicina, 2005.
8. Lim, R.R. A method for the walecation of cumulation and subchronic median effective doss / R. R. Lim, K. J. Rink, H. J. Hass, E. Soage–Echague // Arch. Int. Рharmacodyn. – 1961. – V. 130. – P. 335–353.
Review
For citations:
KOZLOV S.A., MUSAEV M.B. CUMULATIVE PROPERTIES OF NEW DOMESTIC ANTHELMINTIC PREPARATION NADINATE. Russian Journal of Parasitology. 2014;(4):114-116. (In Russ.)
Views:
243
Email this article 