A BIOINFORMATICS CHARACTERIZATION OF THE RNA-DEPENDENT RNA POLYMERASE FROM THE PARASITIC FUNGI, Metarhizium anisopliae
Abstract
Metarhizium anisopliae is an entomopathogenic organism that is parasitic towards insects, including those that serve as vectors for human disease, including malaria parasite infected Anopheles mosquitoes. Directed bioengineering of parasitic M. anisopliae has been proposed as a potentially novel vector control strategy. However, many parasitic fungi posses a RNA-dependent RNA polymerase (RdRp) gene that serves as a defence against transgenes. Here we characterize the RdRp gene of M. anisopliae, including the context of the gene in relation to surrounding genes and theoretical modeling based on the RdRp enzyme of Neurospora crassa.
About the Authors
C. N. WEIR
Walter and Eliza Hall Institute of Medical Research;
University of Melbourne
Australia
Australia
M. Mol. Biol. and Ph. D candidate
1G Royal Parade, Parkville 3052, Victoria
Department of Medical Biology
Parkville 3010, Victoria
E. EWONG
European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton
United Kingdom
United Kingdom
Ph. D.
Cambridgeshire CB10 1SD
G. F. KING
Institute for Molecular Bioscience, University of Queensland
Australia
Australia
Ph. D.
St. Lucia 4072, Brisbane, Queensland
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Review
For citations:
WEIR C., EWONG E., KING G. A BIOINFORMATICS CHARACTERIZATION OF THE RNA-DEPENDENT RNA POLYMERASE FROM THE PARASITIC FUNGI, Metarhizium anisopliae. Russian Journal of Parasitology. 2014;(4):55-63.
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