Acute toxicity of ricazol administered as injection

Abstract

Acute toxicity of Ricazol based on Ricobendazole by oral administration and intramuscular injection in white outbread mice and rats as well as by dermal ad-ministration in white rats is studied. To test the parameters of acute oral toxicity of Ricazol the compound was administered singly to experimental animals (at various doses). General well-being and behavior of animals, manifestation of intoxication symptoms and possible death of animals were observed within 14 days. Post-mortem examination of dead animals was carried out. To investigate acute skin toxicity of Ricazol the compound was given singly to experimental animals on the skin area (size 5cm × 5cm) at the doses of 10000, 15000 и 20000 mg/kg of active ingredient. LD50 value by injection into the stomach for mice was 10000 mg/kg, for male rats – 2500, female rats – 2700 mg/kg. LD50 by dermal administration in rats was 11200 mg/kg, by intramuscular injection in rats – 2500, in male mice – 4900 mg/kg.