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Efficacy of domestic anthelmintic drug mitranox and therapy dose titration against moniesiosis and nematodosis in sheep

Abstract

Efficacy of mitranox, a domestic anthhelmintic drug of the group of acetylated salicylanilides, is tested. Experiments were conducted on sheep spontaneously infected with Mоniezia expansa, М. benedini, gastrointestinal nematodes and Muel- lerius capillaris. Mitranox was administered at the dose of 50, 75 and 100 mg/kg orally, individually, as a single dose in form of water suspension. Efficacy of mi- tranox at moniesiosis at the dose of 50, 75 и 100 mg/kg made respectively 73,3 %, 94,2 и 100 %. The highest efficacy of mitranox applied at the dose of 100 mg/kg against nematodes, gastrointestinal strongylatosis, trichocephalosis and mulleriosis made respectively 97,4 %, 97,2; 86,9 and 93,2 %. The dose of 100 mg/kg is rec- ommended for treatment of moniesiosis and nematodosis in sheep.

About the Authors

S. A. Kozlov
All-Russian Scientific Research Institute of Helminthology named after K.I. Skryabin
Russian Federation
postgraduate


M. B. Musayev
All-Russian Scientific Research Institute of Helminthology named after K.I. Skryabin
Russian Federation
doctor of veterinary sciences


References

1. Arhipov I.A. Antigel'mintiki: farmakologija i primenenie. -M.: Rossel'ho-zakademija, 2009. -404 s.

2. Burjakina A.V., Mihajlicyn F.S., Sevbo D.P. i dr. Ostraja toksichnost' salici-lanilidov, obladajushhih antigel'mintnoj aktivnost'ju//Med. parazitol. i parazit. bol. -2011. -№ 2. -S. 60.

3. Demidov N.V. Antigel'mintiki v veterinarii. -M.: Kolos, 1982. -338 s.

4. Ivashkin V.M., Oripov A.O., Sonin M.D. Opredelitel' gel'mintov melkogo rogatogo skota. -M.: Nauka, 1989. -255 s.

5. Instrukcija o meroprijatijah po preduprezhdeniju i likvidacii zabo-levaemosti zhivotnyh gel'mintozami. -M., 1999. -S. 15.

6. Kozlov S.A., Musaev M.B., Mihajlicyn F.S. i dr. Ostraja toksichnost' anti-gel'mintika mitranoksa//Med. parazitol. i parazit. bol. -2013. -№ 3. -S. 47-48.

7. Kozlov S.A., Musaev M.B., Mihajlicyn F.S. i dr. Jeksperimental'noe izuche-nie kumuljativnyh svojstv novogo preparata mitranoksa//Med. parazitol. i parazit. bol. -2013. -№ 4. -S. 53-54.

8. Lebedeva M.N., Mihajlicyn F.S., Sergiev V.P. Sozdanie otechestvennyh pro-tivoparazitarnyh preparatov//Med. parazitol. i parazit. bol. -2001. -№ 4. -S. 13-16.

9. Sevbo D.P., Sakanjan E.I., Trusov S.N. i dr. Patent RF №2370484: Zaregistrirovan v Gosudarstvennyj Reestr Izobretenij RF 20.10.2009 g.

10. Cherepanov A.A., Moskvin A.S., Kotel'nikov G.A., Hrenov V.M. Dif-feriencial'naja diagnostika gel'mintozov po morfologicheskoj strukture jaic i lichinok vozbuditelej. Atlas. -M.: Kolos, 2000. -76 s.11. Wood J.B., Amaral N.K., Bairden K. et al.//Vet. Parasitol. -1995. -V. 58, № 1/2. -P. 181-213.

11. Coennert R. Sturfe rеconstitution and cestodical effect in the Jomesian series//Abhandl. Med. Chem. Forschungsst. Farbenfabriken Bayer. -1963. -V. 7. -S. 540-567.

12. 5,2/-Dichloro-2-hydroxy-4/-nitrobenzanilide, an antyhelmintic. Farb. Bayer A.-G. (by R. Goenert and E. Schraufstaeffer). Fr. M 2628 Cl. A 61k, c07c) July 24, 1964. -Appl. Ang. 9. 1962. -11 pp.


Review

For citations:


Kozlov S.A., Musayev M.B. Efficacy of domestic anthelmintic drug mitranox and therapy dose titration against moniesiosis and nematodosis in sheep. Russian Journal of Parasitology. 2014;(2):87-91. (In Russ.)

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ISSN 1998-8435 (Print)
ISSN 2541-7843 (Online)