Efficacy of drugs in a solution formulation for external use against nematode and cestode infections in dogs and cats of different age groups
https://doi.org/10.31016/1998-8435-2025-19-3-353-362
Abstract
The purpose of the research is to study therapeutic efficacy of drugs in a solution formulation for external use against nematode and cestode infections in dogs and cats of different age groups.
Materials and methods. The VNIIP – FSC VIEV developed two drugs in a solution formulation for external use based on four active components: imidacloprid, praziquantel, moxidectin, and pyriproxyfen for dogs and cats. The research was conducted on 84 dogs and 72 cats of different sexes, age and body weights spontaneously infected with nematode, cestode, and mixed infections in Moscow and the Moscow Region from August 2018 to November 2024. To treat the animals, the drugs were used once by cutaneous application at a dose of 0.1 mL/kg of body weight. The drug therapeutic efficacy was assessed using the "control test" method, with calculating the average number of parasites detected. The infection rate was determined by examining feces by helminthoovoscopy. The clinical state of the animals was determined using common methods in veterinary medicine. The results underwent common statistical processing.
Results and discussion. The studied drugs showed high therapeutic efficacy 10 days after treatment in the dogs and cats with gastrointestinal nematodosis (Toxocara canis, T. mystax, Toxascaris leonina, Uncinaria stenocephala, and Trichocephalus vulpis), cestodosis (Taenia spp., and Dipylidium caninum) and mixed nematode-cestode infections. No side effects or complications were observed when the drugs were used in the animals of different age groups.
About the Authors
I. P. Belykh
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Belykh Irina P., Candidate of Biological Sciences, Senior Researcher
Researcher ID: U-5007-2018
Scopus ID: 57218097154
Moscow
G. B. Arisova
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Arisova Gulnara B., Candidate of Veterinary Sciences, Leading Researcher of the Laboratory of Experimental Therapy
Researcher ID: U-5425-2018
Scopus ID: 57207925459
Moscow
D. S. Poselov
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Poselov Dmitry S., Candidate of Veterinary Sciences, Senior Researcher
Researcher ID: U-6241-2018
Moscow
A. A. Stepanov
All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV"
Russian Federation
Russian Federation
Stepanov Alexey A., Candidate of Veterinary Sciences, Senior Researcher
Researcher ID: U-8135-2018
Moscow
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For citations:
Belykh I.P., Arisova G.B., Poselov D.S., Stepanov A.A. Efficacy of drugs in a solution formulation for external use against nematode and cestode infections in dogs and cats of different age groups. Russian Journal of Parasitology. 2025;19(3):353-362. (In Russ.) https://doi.org/10.31016/1998-8435-2025-19-3-353-362
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