Studying the efficacy of antiparasitic Doramectin® against nematodosis, acariosis, and entomosis in sheep

The purpose of the research is to study the therapeutic efficacy of antiparasitic Doramectin against nematodosis and arachnoentomosis in sheep.

Materials and methods. The research was performed on a sheep farm on the Romanov sheep (ewes and ewe lambs). Clinical, helminthological (coproovoscopic, larvoscopic), acarological and entomological studies were implemented using standard methods (routine examination, thermometry, and sequential washing, Shcherbovich, Fülleborn, Berman, Weid, and nematode larvae cultivation methods, and microscopic examination of skin scrapings with preliminary detergent treatment). Microscopic equipment used: Biolam, MBS-10, 6x hand magnifying glass. The studied parasitocide Doramectin® (AVZ S.-P.) injection solution is a class of macrocyclic lactones, has a broad spectrum of nematocidal, acaricidal and insecticidal effect, and is used intramuscularly at a dose of 1 mL per 50 kg of live weight (active substance, 10 mg in 1 mL) and remains in a therapeutic concentration in the animal body for up to 28 days.

Results and discussion. The results of the initial laboratory analysis, including helminthological, acarological and entomological study data confirmed a mixed form of gastrointestinal and pulmonary strongylatosis (mulleriosis), strongyloidosis, chorioptosis and melophagosis in sheep. Clinical examination of the animals in the experimental groups showed positive recovery dynamics for three weeks after the initial and repeated therapy courses. Laboratory studies of the ewes and ewe lambs only detected gastrointestinal nematode eggs and larvae in two of 32 cases (EE = 93.8%) on day 8-12 and 15-18, respectively, after a single and double administration of Doramectin. Larvae of protostrongylids Muellerius capillaris and blood flies Melophagus ovinus were not detected (EE = 100%), and mange mites Chorioptes spp. were only detected in one case out of 11 (EE = 91%).

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