Anthelmintic efficacy of complex solid dispersion based on Fenbendazole and Niclozamide against dictyocaulosis and trichuriosis of sheep

The purpose of the research is to study the anthelmintic efficacy of complex solid dispersion of fenbendazole and niclozamide against dictyocaulosis and trichuriosis of sheep.

Materials and methods. The complex solid dispersion was obtained by mechanochemical processing of fenbendazole (FBZ), niclozamide (NZM) and polyvinylpyrrolidone (PVP) substances in the ratio of 2 : 20 : 78. The obtained samples of solid dispersion were studied for nematocidal activity on sheep naturally infected with Dictyocaulus filaria and Trichuris ovis. The solid dispersion was tested against dictyocaulosis of sheep at a dose of 2 mg/kg and against trichuriosis at doses of 2, 4 and 6 mg/kg according to FBZ.

Results and discussion. The complex dispersion based on FBZ, NZM and PVP showed 98.9% efficacy against dictyocaulosis of sheep at a dose of 2 mg/kg according to FBZ. The basic preparation – a mechanical mixture of FBZ and NZM at the same dose revealed 25.8% effect. Against trichuriosis of sheep, 98.7; 93.5 and 78.8% efficacy of complex solid dispersion was obtained at doses of 6, 4 and 2 mg/kg according to the active substance, respectively. The mechanical mixture of FBZ and NZM showed a 24.6% effect at a dose of 6 mg/kg according to FBZ. The dose of the complex solid dispersion – 6 mg/kg according to FBZ is recommended as therapeutic against trichuriosis of sheep.

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