Antiprotozoal efficacy of a supramolecular drug based on 5% toltrazuril against experimental eimeriosis in broiler chickens

The purpose of the research is to obtain 5% toltrazuril supramolecular forms with the addition of SASs and emulsifiers, and to study antiprotozoal activity in a limited period of their introduction into the poultry diet with water.

Materials and methods. Toltrazuril supramolecular forms were obtained by the mechanochemical suspension method with the addition of auxiliary excipients (emulsifier, SASs, etc.). A mixture consisting of following three types of coccidia of chickens was used to infect the chickens: Eimeria acervulina, E. tenella, and E. maxima. The following drugs were tested: Stop-coccid 2.5%, Supramolecular Toltrazuril 5% with SASs, Supramolecular Toltrazuril 5% with Emulsifier, and Toltrazuril 5%. Six groups (two control and four experimental) of 7 broiler chickens aged 15 days were formed. The chickens from one control and four experimental groups were infected with a mixture of sporulated coccidia oocysts. The reproduction level of coccidia oocysts excreted by one chicken and in 1 g of droppings from the experimental chickens was calculated during the 5-day patent period. The birds of each group were weighed at the beginning and the end of the experiment. The intense-effectiveness of the drug and the reproductive index were calculated. A diagnostic dissection of the forcedly killed birds was performed.

Results and discussion. It was found that Supramolecular Toltrazuril 5% with SASs and Supramolecular Toltrazuril 5% with Emulsifier gave the most reduced reproduction of coccidia oocysts in experimental coccidiosis as compared to the other experimental groups. The intense-effectiveness of these drugs was the highest as compared to the other groups.

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