Effect of albendazole supramolecular complex on sheep organism

Abstract

The purpose of the research is to study the effect of albendazole supramolecular complex on clinical, hematological and biochemical parameters of sheep.
Materials and methods. The effect of albendazole supramolecular complex on sheep organism was studied on 20 sheep weighing 34–42 kg, divided into 4 groups of 5 animals each. Sheep of Groups 1, 2 and 3 were administered the drug orally, once, at the therapeutic dose by AS 3 times 6 mg/kg and in 5 times increased doses (10 mg/kg). Animals to which the drug was not applied served as the control. Blood samples for hematologic and biochemical studies were taken from the jugular vein of animals at the same time - in the morning before the first injection and after 1, 3 and 5 days. The clinical condition of the animals, feed and water intake were daily monitored. Body temperature, number of heart beats, respiratory movements and rumen contractions per 2 min were taken into account. Hematological parameters of sheep were determined on PSE 90-vet analyzer (China), leukogram was determined by the generally accepted method. Blood biochemical parameters were studied using a BioSystems A15 analyzer (Spain).
Results and discussion. Clinical and hematological indices of sheep after administration of the drug in tested doses were within the limits of physiological standard during the whole period of the research. The leukocyte profile in experimental and control sheep remained unchanged throughout the experiment (P < 0.05). At oral administration of the drug at a dose of 5.0 mg/kg of AS, no significant changes were observed in biochemical parameters of sheep blood, except for a shortterm increase in the content of creatinine and urea.