Clinical experience with the use and efficacy evaluation of new Insacar Total C Plus for dogs and Insacar Total K Plus for cats
https://doi.org/10.31016/1998-8435-2023-17-2-265-275
Abstract
The purpose of the research is to study the efficacy of new multicomponent drugs for dogs and cats against arachnoentomosis and helminthosis.
Materials and methods. The efficacy of new four-component Insacar Total C Plus Drops for Dogs and Insacar Total K Plus Drops for Cats was studied on target animal species. The experiment included 90 dogs and 82 cats including 38 dogs and 37 cats with monoinfection by ticks (Sarcoptes canis, Demodex canis, Notoedres cati, Otodectes cynotis, family Ixodidae), 39 dogs and 31 cats with monoinfection by insects (Ctenocephalides sp., Linognathus setosus, Trichodectes canis), 13 dogs and 14 cats with infection by helminths (Toxocara canis, T. cati, Toxascaris leonina, Taenia sp.), and 13 dogs and 10 cats with mixed infections. The drug was applied to the skin of the animals in dosages as specified in the instructions for use. The therapy effectiveness was monitored on days 14 and 28, and in case of Notoedres cati and Sarcoptes canis, on day 40.
Results and discussion. The efficacy of multicomponent drugs against monoinfections with insects, ixodid ticks, ticks of the genus Demodex and helminths, as well as mixed infections of the dogs and cats was 100% in clinical studies. The efficacy in the cats with notoedric mange was 80%, and 83.4% in the dogs with sarcoptic mange. The advantage of four-component Insacar Total C Plus Drops for Dogs and Insacar Total K Plus Drops for Cats is the presence of several components, namely, imidacloprid, praziquantel, pyriproxyfen, and moxidectin. The unique combination of active ingredients ensures the efficacy of drugs against external and internal parasites including ixodid ticks, and preventive efficacy against entomosis and ixodid ticks for 30 days. The drops for dogs and cats are advisable against mixed infections.
About the Author
N. V. MakhvatovaRussian Federation
Makhvatova Nadezhda V., Postgraduate Student
28, Bolshaya Cheremushkinskaya st., Moscow, 117218
References
1. Avdyukhina T. I., Konstantinova T. N., Dovgalev A. S., Belyaev A. E., Imamkuliev K. D., Gorbunova Yu. P. Laboratory diagnosis of helminth infections. Section 1. Nematode infections. Study guide. Мoscow: Russian Medical Academy of Post-Graduate Education, 2012; 49. (In Russ.)
2. Arisov M. V., Arisova G. B., Loganov A. V., Testing of insecticidal efficacy of Insacar against entomosis of dogs. «Teoriya i praktika bor'by s parazitarnymi boleznyami»: materialy nauchnoy konferentsii Vseros. o-va gel'mintol. RAN = "Theory and practice of parasitic disease control": proceedings of the Scientific Conference of the All-Russian Society of Helminthologists of the Russian Academy of Sciences. Мoscow, 2011; 12: 27–28. (In Russ.)
3. Arisov M. V., Arkhipov I. A. Methods for determining the efficacy of insecticides, acaricides, growth regulators and repellents against ectoparasitosis of carnivores. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2018; 12 (1): 81–97. (In Russ.) https://doi.org/10.31016/1998-8435-2018-12-1-81-97
4. Arisova G. B., Balyshev A. V., Belykh I. P., Semenova N. V., Artemov V. V. Study of pharmacokinetic parameters and efficacy of Inspector Quadro C and Inspector Quadro K against endoparasitosis in dogs and cats. Veterïnarïya = Veterinary Medicine. 2019; 5: 51–55. (In Russ.) https://doi.org/10.30896/0042-4846.2019.22.51-54
5. Arisov M. V., Belykh I. P., Artemov V. V., Inspector Quadro is a combined drug for treatment of ectoand endoparasitosis in dogs and cats. Rossiyskiy parazitologicheskiy zhurnal = Russian Journal of Parasitology. 2018; 12 (2): 75–84. (In Russ.) https://doi.org/10.31016/1998-8435-2018-12-2-75-84
6. Arisov M. V., Indyuhova E. N., Kuznetsova E. A., Arisova G. B., Smirnova E. S. Gelmintal tablets is a new combined moxidectin and praziquantelbased drug for treatment of endoparasitosis in dogs. Uchenyye zapiski Kazanskoy gosudarstvennoy akademii veterinarnoy meditsiny im. N. E. Baumana = Scientific notes of the Kazan State Academy of Veterinary Medicine named after N. E. Bauman. 2015; 223 (3): 12–15. (In Russ.)
7. Balashov Yu. S. Parasitism of ticks and insects on terrestrial vertebrates. St. Petersburg: Nauka, 2009. 357 p.
8. Belykh I. P., Arisova G. B., Artemov V. V., Semenova N. V. Effective treatment and prevention of ectoparasites infections in dogs and cats with Inspector Quadro for outward application. «Sovremennyye problem obshchey i chastnoy parazitologii»: materialy III konferentsii = Current issues of general and special parasitology: proceedings of the III Conference. St. Petersburg. 2019; 57–59. (In Russ.) https://doi.org/10.31857/S123456780602008X
9. Vasilevich F. I. Gastrointestinal nematode and cestode infections of dogs. Veterïnarïya = Veterinary Medicine. 1997; 2: 53–55. (In Russ.)
10. Gavrilova N. A. Sarcoptic mange in carnivores. Vetfarma = VetPharma. 2012; 1–2: 50–53. (In Russ.)
11. Gavrilova N. A. The use of Inspector Total against mixed infections of carnivores. Vetfarma = VetPharma. 2013; 1 (12): 54–56. (In Russ.)
12. Domatsky V. N. Means of parasitosis therapy and prevention in dogs and cats. Uspekhi sovremennoy nauki = Successes of modern science. 2016; 9 (11): 93–96. (In Russ.)
13. Makhvatova N.V. Acute and subchronic toxicity of multicomponent antiparasitic drugs Insaсar Total C Plus, Insaсar Total K Plus. Russian Journal of Parasitology. 2022; 16(2): 193–202. (In Russ.) https://doi.org/10.31016/1998-8435-2022-16-2-193-202
14. Müller R. S. Sarcoptic mange, demodicosis and otodectosis in dogs: treatment methods. Vetfarma = VetPharma. 2012; 1–2: 42–44. (In Russ.)
15. Cherepanov A. A., Moskvin A. S., Kotelnikov G. A., Khrenov V. M. Differential diagnosis of helminth infections according to the morphological structure of eggs and larvae of pathogens. Мoscow: Kolos, 2001; 76. (In Russ.)
16. Farrakhov A. I., Latypov D. G. The effectiveness of various laboratory methods for the diagnosis of sarcoptic mange in pigs. Scientific notes of the Kazan State Academy of Veterinary Medicine named after N. E. Bauman. 2014; 219 (3): 304–309. (In Russ.)
17. ESCCAP. Control of Parasitic Mites in Dogs and Cats. Guideline No. 4. 2009; 18.
18. ESCCAP. Control of Ectoparasites in Dogs and Cats. Guideline No. 3. 2018; 34.
19. Williams Ralph E. (Ralph Edward) 1949-Veterinary entomology: livestock and companion animals. 2010; 348.
20. Zajac A. M., Conboy G. A. Veterinary clinical parasitology. 8rd edn. Wiley-Blackwell, Chichester. 2012; 3–68.
Review
For citations:
Makhvatova N.V. Clinical experience with the use and efficacy evaluation of new Insacar Total C Plus for dogs and Insacar Total K Plus for cats. Russian Journal of Parasitology. 2023;17(2):265-275. (In Russ.) https://doi.org/10.31016/1998-8435-2023-17-2-265-275