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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vniigis</journal-id><journal-title-group><journal-title xml:lang="ru">Российский паразитологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Parasitology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-8435</issn><issn pub-type="epub">2541-7843</issn><publisher><publisher-name>ВНИИП – филиал ФГБНУ ФНЦ ВИЭВ РАН</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vniigis-283</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПАТОГЕНЕЗ, ПАТОЛОГИЯ И ЭКОНОМИЧЕСКИЙ УЩЕРБ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PATHOGENEZIS, PATHOLOGY AND ECONOMIC DAMAGE</subject></subj-group></article-categories><title-group><article-title>ПОКАЗАТЕЛИ ГУМОРАЛЬНОГО ИММУНИТЕТА У ТЕЛЯТ ПРИ КРИПТОСПОРИДИОЗЕ</article-title><trans-title-group xml:lang="en"><trans-title>VALUES OF HUMORAL IMMUNITY IN CALVES AT CRYPTOSPORIDIOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ЯКУБОВСКИЙ</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>YAKUBOVSKY</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор ветеринарных наук </p><p>ул. Брикета, д. 28</p></bio><bio xml:lang="en"><p>doctor of veterinary sciences </p><p>28 Briket str.</p></bio><email xlink:type="simple">bievm@tut.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ПЕПЕЛЯЕВА</surname><given-names>О. П.</given-names></name><name name-style="western" xml:lang="en"><surname>PEPELYAEVA</surname><given-names>O. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>соискатель </p><p>ул. Брикета, д. 28</p></bio><bio xml:lang="en"><p>candidate </p><p>28 Briket str.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт экспериментальной ветеринарии им. С.Н. Вышелесского, г. Минск</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Institute of Experimental Veterinary Medicine named after S. N. Vyshelessky, Minsk</institution><country>Belarus</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>14</day><month>05</month><year>2016</year></pub-date><volume>0</volume><issue>4</issue><fpage>44</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ЯКУБОВСКИЙ М.В., ПЕПЕЛЯЕВА О.П., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">ЯКУБОВСКИЙ М.В., ПЕПЕЛЯЕВА О.П.</copyright-holder><copyright-holder xml:lang="en">YAKUBOVSKY M.V., PEPELYAEVA O.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vniigis.elpub.ru/jour/article/view/283">https://vniigis.elpub.ru/jour/article/view/283</self-uri><abstract><p>В опытах на телятах в возрасте 9–35 сут, спонтанно инвазированных криптоспоридиями, изучена динамика циркулирующих иммунных комплексов и иммуноглобулинов G, M, A в развитии патологического процесса. У зараженных телят отмечали снижение содержания иммуноглобулинов G на 23,1 %, повышение иммуноглобулинов A на 55,7 % и увеличение циркулирующих иммунных комплексов в 2,38 раза по сравнению с показателями животных контрольной группы, что свидетельствует о наличии специфического взаимодействия антиген–антитело и уменьшении активности гуморального звена иммунной системы. Инвазия, вызванная криптоспоридиями, приводит к патофизиологическим изменениям в гуморальной иммунной системе телят, что проявляется снижением уровня иммуноглобулина G и повышением уровня иммуноглобулина A и циркулирующих иммунных комплексов. </p></abstract><trans-abstract xml:lang="en"><p>Dynamics of circulating immune complexes and immunoglobulins G, M, A during a pathological process are studied in experiments on calves in the age of 9– 35 days spontaneously infected with Cryptosporidia spp. The decreased level of immunoglobulin G (by 23,1 %), the increased level of immunoglobulin A (by 55,7 % ) and the increased by 2,38 times amount of circulating immune complexes were found in infected calves in comparison with the values of the control group that confirms the presence of the specific interaction antigen-antibody and the decreased activity of the humoral component of immune system. Infection caused by Cryptosporidia spp. leads to pathophysiological changes in humoral immune system of calves that is manifested in a decreased level of immunoglobulin G and an increased level of immunoglobulin A as well as in an increased amount of circulating immune complexes. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>криптоспоридиоз</kwd><kwd>иммуноглобулины</kwd><kwd>циркулирующие иммунные комплексы</kwd><kwd>телята</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cryptosporidosis</kwd><kwd>immunoglobulins</kwd><kwd>circulating immune complexes</kwd><kwd>calves</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ershov, V. S. // Probl. vet. immunologii. – M.: Agropromizdat, 1985. – S. 17–22.</mixed-citation><mixed-citation xml:lang="en">Ershov, V. 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