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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vniigis</journal-id><journal-title-group><journal-title xml:lang="ru">Российский паразитологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Parasitology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-8435</issn><issn pub-type="epub">2541-7843</issn><publisher><publisher-name>ВНИИП – филиал ФГБНУ ФНЦ ВИЭВ РАН</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vniigis-282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПАТОГЕНЕЗ, ПАТОЛОГИЯ И ЭКОНОМИЧЕСКИЙ УЩЕРБ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PATHOGENEZIS, PATHOLOGY AND ECONOMIC DAMAGE</subject></subj-group></article-categories><title-group><article-title>ПАТОГЕНЕЗ ДЕРМАТИТОВ ДЕМОДЕКОЗНОЙ ЭТИОЛОГИИ У СОБАК</article-title><trans-title-group xml:lang="en"><trans-title>PATHOGENESIS OF DERMATITIS OF DEMODECOSIS ETIOLOGY IN DOGS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ШАПОВАЛОВА</surname><given-names>О.</given-names></name><name name-style="western" xml:lang="en"><surname>SHAPOVALOVA</surname><given-names>O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант</p><p>109316, ул. Талалихина, 33</p></bio><bio xml:lang="en"><p>postgraduate </p><p>109316, Talalihin st., 33</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ГЛАМАЗДИН</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>I. G. GLAMAZDIN</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор ветеринарных наук </p><p>111621, ул. Оренбургская 15 Б, ком.404 </p></bio><bio xml:lang="en"><p>doctor of veterinary sciences </p><p>111621, Orenburgskaya st. 15 B, room 404 </p></bio><email xlink:type="simple">glamazdin@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>СЫСОЕВА</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>SYSOEVA</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат ветеринарных наук </p><p>109316, ул. Талалихина, 33</p></bio><bio xml:lang="en"><p>PhD in veterinary sciences </p><p>109316, Talalihin st., 33</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный университет пищевых производств, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State University of Food Production, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российская академия кадрового обеспечения агропромышленного комплекса, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Academy of Staffing of Agroindustrial Complex, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>14</day><month>05</month><year>2016</year></pub-date><volume>0</volume><issue>4</issue><fpage>40</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ШАПОВАЛОВА О., ГЛАМАЗДИН И.Г., СЫСОЕВА Н.Ю., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">ШАПОВАЛОВА О., ГЛАМАЗДИН И.Г., СЫСОЕВА Н.Ю.</copyright-holder><copyright-holder xml:lang="en">SHAPOVALOVA O., I. G. GLAMAZDIN I.G., SYSOEVA N.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vniigis.elpub.ru/jour/article/view/282">https://vniigis.elpub.ru/jour/article/view/282</self-uri><abstract><p>Изучены вопросы демодекозной инвазии среди популяции московских собак; установлена зависимость акцентов патогенеза болезни от возраста и породы животных. Установлено, что с возрастом риск возникновения острого демодекоза увеличивается, а у самок такой риск возрастает во время течки. Определены биохимические показатели повреждения внутренних органов: общий белок, глюкоза, мочевина, креатинин, активность АЛТ и АСТ в сыворотке крови собак. У собак с низкой и средней степенью инвазии среднее значение АсАТ и АлАТ составило соответственно 51,05± 2,64 и 98,69±3,85 МЕ/л, с высокой степенью инвазии – 57,31± 2,91 и 131,09±3,65 МЕ/л. Отмечено повышение уровня креатинина и снижение глюкозы в сыворотке крови собак всех опытных групп. Наибольшие изменения установлены в уровне креатинина и глюкозы – до 87,41±3,85 мкмоль и 3,91±0,21 ммоль соответственно. Демодекоз необходимо рассматривать как комплексную проблему, требующую тщательного исследования ферментного и гормонального статуса. </p></abstract><trans-abstract xml:lang="en"><p>Issues on demodecosis infection in dog population of Moscow have been studied; the dependence between the accents in the pathogenesis and the age and dog breed has been determined. The risk of acute demodecosis increases with the age, and in female dogs such risk goes up during their heat cycles. Biochemical values of the damage to internal organs: the total protein, glucose, urea, creatinine, activity of aspartate aminotransferase (AST) and alanine transaminase (ALT) in dogs’ blood have been estimated. In dogs with low and medium infection rates the average AST and ALT values were 51,05±2,64 and 98,69±3,85 u/l respectively, with a high infection rate 57,31±2,91 and 131,09±3,65 u/l. The increase of creatinine level and decrease in blood glucose of all tested dogs’ groups were observed. The most significant changes were determined in the levels of creatinine and glucose: up to 87,41±3,85 mkmol and 3,91±0,21 mmol respectively. Demodecosis should be considered as a complex issue requiring a detailed examination of enzyme levels and hormonal status. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>демодекоз</kwd><kwd>биохимические показатели</kwd><kwd>патогенез</kwd><kwd>собаки</kwd></kwd-group><kwd-group xml:lang="en"><kwd>demodecosis</kwd><kwd>biochemical values</kwd><kwd>pathogenesis</kwd><kwd>dogs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Glamazdin, I. G. Demodekoz [Jelektronnyj resurs] / I. G. Glamazdin, O. A. Fedorchenko. – Rezhim dostupa: http:// Veterinary/Demodex1.htm</mixed-citation><mixed-citation xml:lang="en">Glamazdin, I. G. Demodekoz [Jelektronnyj resurs] / I. G. Glamazdin, O. A. 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