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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vniigis</journal-id><journal-title-group><journal-title xml:lang="ru">Российский паразитологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Parasitology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-8435</issn><issn pub-type="epub">2541-7843</issn><publisher><publisher-name>ВНИИП – филиал ФГБНУ ФНЦ ВИЭВ РАН</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vniigis-226</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОЛОГИЯ, ТОКСИКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOLOGY, TOXICOLOGY</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА ЭМБРИОТОКСИЧЕСКОГО И ТЕРАТОГЕННОГО ДЕЙСТВИЙ ИВЕРМЕКТИНА У ЛАБОРАТОРНЫХ ЖИВОТНЫХ</article-title><trans-title-group xml:lang="en"><trans-title>Estimation of embryotoxic and teratogenic effects of ivermectin in laboratory animals</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ЕМЕЛЬЯНОВА</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Yemelyanova</surname><given-names>N. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат биологических наук</p></bio><bio xml:lang="en"><p>PhD in biological sciences</p></bio><email xlink:type="simple">emelyanova13@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>САМОЙЛОВСКАЯ</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Samoylovskaya</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат биологических наук</p></bio><bio xml:lang="en"><p>PhD in biological sciences</p></bio><email xlink:type="simple">rhodiola_rosea@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Всероссийский научно-исследовательский институт гельминтологии им. К.И. Скрябина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>All-Russian Scientific Research Institute of Helminthology named after K.I. Skryabin</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>05</month><year>2016</year></pub-date><volume>0</volume><issue>2</issue><fpage>98</fpage><lpage>103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ЕМЕЛЬЯНОВА Н.Б., САМОЙЛОВСКАЯ Н.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">ЕМЕЛЬЯНОВА Н.Б., САМОЙЛОВСКАЯ Н.А.</copyright-holder><copyright-holder xml:lang="en">Yemelyanova N.B., Samoylovskaya N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vniigis.elpub.ru/jour/article/view/226">https://vniigis.elpub.ru/jour/article/view/226</self-uri><abstract><p>Проведены исследования по изучению эмбрио- тропного действия ивермектина (субстанция) в тера- певтической дозе 0,2 мг/кг. Установлено, что в тести- руемой дозе ивермектин не обладает эмбриотоксиче- ским и тератогенным эффектом</p></abstract><trans-abstract xml:lang="en"><p>Injection of ivermectin in a dose of 0,2 mg/kg to pregnant rates in critical stage of embryogenesis at days 1-6, 7-14 and 15-19 did not effect animals’ beha- vior. Duration of pregnancy in laboratory female rats was at control and normal physiological level for present kind of animas. Delivery process was normal with- out clinical features and complications. Presence of milk in rats’ stomachs allows to conclude that the injection of tested medicine to female rats did not affect their lactation and sucking reflex. At injection of ivermectin in a therapeutic dose at days 1-6, 7-14 and 15-19 of pregnancy the value of rats' death in the first life month was compatible with control values. According to our observation there was no effect of ivermectin on postnatal development in rats in form of death and external malformations. All rats were born healthy, responded well to external stimuli, had a good appetite and pursued an active life. Results of laboratory research allow to conclude that ivermectin injection to rats in a therapeutic dose of 0,2 mg/kg in dif- ferent pregnancy terms including critical stages doesn't have embryotoxic and tera- togenic effects</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ивермектин</kwd><kwd>терапевтическая доза</kwd><kwd>беспородные крысы</kwd><kwd>эмбриотоксический эффект</kwd><kwd>тератогенное действие</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ivermectin</kwd><kwd>therapeutic dose</kwd><kwd>nonbreeding rats</kwd><kwd>embryotoxic effects</kwd><kwd>teratogenic effects</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Veselova T.P. 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