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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vniigis</journal-id><journal-title-group><journal-title xml:lang="ru">Российский паразитологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Parasitology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1998-8435</issn><issn pub-type="epub">2541-7843</issn><publisher><publisher-name>ВНИИП – филиал ФГБНУ ФНЦ ВИЭВ РАН</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vniigis-213</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПАТОГЕНЕЗ, ПАТОЛОГИЯ И ЭКОНОМИЧЕСКИЙ УЩЕРБ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PATHOGENEZIS, PATHOLOGY AND ECONOMIC DAMAGE</subject></subj-group></article-categories><title-group><article-title>КАРИОПАТИЧЕСКОЕ ДЕЙСТВИЕ ЭКСТРАКТА Fasciola hepatica НА ЛАБОРАТОРНЫХ МЫШЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>Caryopathic effect of extract Fasciola hepatica on laboratory mice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>КРАСНИКОВА</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnikova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>соискатель</p></bio><bio xml:lang="en"><p>candidate</p></bio><email xlink:type="simple">Viki-eva1002@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>СИВКОВА</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sivkova</surname><given-names>T. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор биологических наук</p></bio><bio xml:lang="en"><p>doctor of biological sciences</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Пермская государственная сельскохозяйственная академия им. акад. Д.Н. Прянишникова<country>Россия</country></aff><aff xml:lang="en">Perm State Agricultural Academy named after Academician D.N. Pryanishnikov<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>05</month><year>2016</year></pub-date><volume>0</volume><issue>2</issue><fpage>51</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; КРАСНИКОВА Е.В., СИВКОВА Т.Н., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">КРАСНИКОВА Е.В., СИВКОВА Т.Н.</copyright-holder><copyright-holder xml:lang="en">Krasnikova E.V., Sivkova T.N.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vniigis.elpub.ru/jour/article/view/213">https://vniigis.elpub.ru/jour/article/view/213</self-uri><abstract><p>Изучено воздействие экстракта трематод Fasciola hepatica на клетки организма лабораторных мышей. Очищенный экстракт фасциол однократно внутри- брюшинно вводили нелинейным белым мышам- самцам в дозе 100 мкг белка. Проведен учет количест- ва лейкоцитов, лимфоцитов, моноцитов и гранулоци- тов. Мазки крови и мазки-отпечатки красного костно- го мозга и семенников окрашивали по Романовскому и микроскопировали. Определяли митотический ин- декс и подсчитывали число патологических фигур ми- тоза. Установлено, что однократное внутрибрюшинное введение лабораторным белым мышам соматического экстракта F. hepatica повышает число анэуплоидных клеток в красном костном мозге, а также стимулирует выработку лимфоцитов и эозинофилов. Полученные результаты подтверждают способность гельминтов вызывать нарушения процесса деления клеток в ор- ганизме хозяина</p></abstract><trans-abstract xml:lang="en"><p>Effect of extract of trematodes Fasciola hepatica on body cells of laboratory mice is studied. A single intraperitoneal injection of rectified extract of fascioles was made into non-linear white male mice at the dose of 100 mg/kg of extract en- zyme. The total number of leucocytes, lymphocytes, monocytes and granulocytes has been registered. Blood films as well as red bone marrow- and seminal vesicles smears were stained using a Romanowsky - type stain and microscoped. Mitotic index was determined and number of abnormal mitotic figures calculated. It is found that a single intraperitoneal injection of rectified extract F. hepatica into non-linear white male mice increases the number of aneuploid cells of red bone marrow as well as stimulates production of lymphocytes and eosinophils. The re- ceived results confirm the ability of helminths to cause the host cell mitotic distur- bances</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фасциолез</kwd><kwd>соматический экстракт</kwd><kwd>клетки крови</kwd><kwd>костный мозг</kwd><kwd>митоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>fascioliasis</kwd><kwd>somatic extract</kwd><kwd>blood cells</kwd><kwd>bone marrow</kwd><kwd>mitosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Akbaev M.Sh., Vodjanov A.A., Kosminkov N.E. Parazitologija i invazi-onnye bolezni zhivotnyh. -M.: Kolos, 1998. -743 s.</mixed-citation><mixed-citation xml:lang="en">Akbaev M.Sh., Vodjanov A.A., Kosminkov N.E. Parazitologija i invazi-onnye bolezni zhivotnyh. -M.: Kolos, 1998. -743 s.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bekish O.-Ja.L. Bekish V.Ja., Pobjarzhin V.V. Genotoksicheskie i cito-toksicheskie jeffekty v organizme hozjaina pri gel'mintoznyh invazijah//Dostizhenija medicinskoj nauki Belorussii. -2006.</mixed-citation><mixed-citation xml:lang="en">Bekish O.-Ja.L. Bekish V.Ja., Pobjarzhin V.V. Genotoksicheskie i cito-toksicheskie jeffekty v organizme hozjaina pri gel'mintoznyh invazijah//Dostizhenija medicinskoj nauki Belorussii. -2006.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bekish V.Ja., Malyshev I.Ju. Vozdejstvie metabolitov migrirujushhih lichinok askarid na nasledstvennyj apparat spermatogoniev i spermatocitov hozjaina//Mater. 11 konf. mol. uch. Rossii «Fundamental'nye nauki i progress klinicheskoj mediciny». -M., 2001. -Tom 22. -S. 127.</mixed-citation><mixed-citation xml:lang="en">Bekish V.Ja., Malyshev I.Ju. Vozdejstvie metabolitov migrirujushhih lichinok askarid na nasledstvennyj apparat spermatogoniev i spermatocitov hozjaina//Mater. 11 konf. mol. uch. Rossii «Fundamental'nye nauki i progress klinicheskoj mediciny». -M., 2001. -Tom 22. -S. 127.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Vasil'eva V.A. Jepizootologicheskaja situacija fascioleza krupnogo ro-gatogo skota v Rossijskoj Federacii//Estestvoznanie i gumanizm. -2008. -T. 5, Vyp. 1. -S. 23-26.</mixed-citation><mixed-citation xml:lang="en">Vasil'eva V.A. Jepizootologicheskaja situacija fascioleza krupnogo ro-gatogo skota v Rossijskoj Federacii//Estestvoznanie i gumanizm. -2008. -T. 5, Vyp. 1. -S. 23-26.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Il'inskih I.N., Novickij V.V., Il'inskih E.N. i dr. Infekcionnaja kariopatologija/Pod red. N.N. Il'inskih. -Tomsk: Izd-vo Tom. un-ta, 2005. -168 s.</mixed-citation><mixed-citation xml:lang="en">Il'inskih I.N., Novickij V.V., Il'inskih E.N. i dr. Infekcionnaja kariopatologija/Pod red. N.N. Il'inskih. -Tomsk: Izd-vo Tom. un-ta, 2005. -168 s.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kalinin L.V. Vlijanie trihinelleznoj invazii i metabolitov trihinell na hromo-somnyj apparat somaticheskih kletok hozjaina: Avtoref. dis.. kand. med. nauk. -Vitebsk, 1995. -19 s.</mixed-citation><mixed-citation xml:lang="en">Kalinin L.V. Vlijanie trihinelleznoj invazii i metabolitov trihinell na hromo-somnyj apparat somaticheskih kletok hozjaina: Avtoref. dis.. kand. med. nauk. -Vitebsk, 1995. -19 s.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kolesnikova M.A. Issledovanie geograficheskih informacionnyh sistem dlja jepizootolocheskih prirodnyh izotopov fasciol//Veterinarija. -2008. -№ 6. -S. 35-38.</mixed-citation><mixed-citation xml:lang="en">Kolesnikova M.A. Issledovanie geograficheskih informacionnyh sistem dlja jepizootolocheskih prirodnyh izotopov fasciol//Veterinarija. -2008. -№ 6. -S. 35-38.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kumysheva Ju.A. Fasciolez krupnogo rogatogo skota i ego vlijanie na fiziko-himicheskie pokazatele produktov uboja: Avtoref. dis.. kand. biol. nauk. -M., 2009. -24 s.</mixed-citation><mixed-citation xml:lang="en">Kumysheva Ju.A. Fasciolez krupnogo rogatogo skota i ego vlijanie na fiziko-himicheskie pokazatele produktov uboja: Avtoref. dis.. kand. biol. nauk. -M., 2009. -24 s.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Maksimenko S.N. Vlijanie nematodoznoj invazii na mitoz, antimito-ticheskoe dejstvie i biotransformaciju albendazola u laboratornyh zhivotnyh: Avto-ref. dis.. kand. vet nauk. -M., 2008. -23 s.</mixed-citation><mixed-citation xml:lang="en">Maksimenko S.N. Vlijanie nematodoznoj invazii na mitoz, antimito-ticheskoe dejstvie i biotransformaciju albendazola u laboratornyh zhivotnyh: Avto-ref. dis.. kand. vet nauk. -M., 2008. -23 s.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sivkova T.N. Poluchenie i hranenie antigenov gel'mintov. -Perm': Izd-vo FGOU VPO Permskaja GSHA, 2009. -14 s.</mixed-citation><mixed-citation xml:lang="en">Sivkova T.N. Poluchenie i hranenie antigenov gel'mintov. -Perm': Izd-vo FGOU VPO Permskaja GSHA, 2009. -14 s.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sheljakin I.D. Antioksidantnaja zashhita krupnogo rogatogo skota pri fascioleze//Veterinarija. -2008. -№ 4. -S. 27-29.</mixed-citation><mixed-citation xml:lang="en">Sheljakin I.D. Antioksidantnaja zashhita krupnogo rogatogo skota pri fascioleze//Veterinarija. -2008. -№ 4. -S. 27-29.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
