vniigisРоссийский паразитологический журналRussian Journal of Parasitology1998-84352541-7843ВНИИП – филиал ФГБНУ ФНЦ ВИЭВ РАНvniigis-173Research ArticleЛЕЧЕНИЕ И ПРОФИЛАКТИКАTREATMENT AND PREVENTIONОБЗОР ПРИМЕНЕНИЯ ПРОТИВОМАЛЯРИЙНЫХ ПРЕПАРАТОВ, ПРИМЕРЫ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ И ЕЕ ВЛИЯНИЕ НА ЭФФЕКТИВНОСТЬ ПРОГРАММ ВСЕМИРНОЙ ОРГАНИЗАЦИИ ЗДРАВООХРАНЕНИЯ (ВОЗ)REVIEWING ANTI-MALARIAL USAGE AND RESISTANCE PATTERNS AND ITS EFFECTS ON WORLD HEALTH ORGANISATION PROGRAMSKocovskiNikolceKocovskiNikolceweir.c@wehi.edu.auGodfrey L. L. BWilliamGodfrey L. L. BWilliamweir.c@wehi.edu.auElkington B. ScDerekElkington B. ScDerekweir.c@wehi.edu.auWeir B. ScChristopherWeir B. ScChristopherweir.c@wehi.edu.auOlivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University, Austin Health, Heidelberg 3084, Victoria, AustraliaАвстралияOlivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University, Austin Health, Heidelberg 3084, Victoria, AustraliaAustraliaThe School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, Queensland, AustraliaАвстралияThe School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, Queensland, AustraliaAustraliaSchool of Pathology and Laboratory Medicine, University of Western Australia, Crawley 6009, Western Australia, AustraliaАвстралияSchool of Pathology and Laboratory Medicine, University of Western Australia, Crawley 6009, Western Australia, AustraliaAustraliaWalter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia; University of Melbourne, Department of Medical Biology, Parkville 3010, Victoria, Australia; University of Edinburgh, School of Chemistry, Edinburgh EH9 3FJ, Scotland, United Kingdom.АвстралияWalter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia; University of Melbourne, Department of Medical Biology, Parkville 3010, Victoria, Australia; University of Edinburgh, School of Chemistry, Edinburgh EH9 3FJ, Scotland, United Kingdom.Australia201508052016036574Copyright © Kocovski N., Godfrey L. L. B W., Elkington B. Sc D., Weir B. Sc C., 20162016Kocovski N., Godfrey L. L. B W., Elkington B. Sc D., Weir B. Sc C.Kocovski N., Godfrey L. L. B W., Elkington B. Sc D., Weir B. Sc C.This work is licensed under a Creative Commons Attribution 4.0 License.https://vniigis.elpub.ru/jour/article/view/173

Проблема, касающаяся лечения  этих  болезней,  это проблема устойчивости к лекарственным  препаратам. Устойчивость к лекарственным препаратам часто возникает вследствие ключевых мутаций при неправильном выборе метода лечения, и уже продемонстрировала  свою способность к глобальному распространению,  затрудняя дальнейшую разработку современных  и более эффективных лечебных программ, таких как программы Всемирной Организации Здравоохранения (ВОЗ). В этой статье мы рассматриваем историю применения противомалярийных средств, развитие устойчивости к ним в Африке и Азии, механизм действия лекарственных препаратов и лекарственную устойчивость,  а также влияние устойчивости на политику ВОЗ. 

The two most significant strains of human malaria parasites responsible for morbidity and mortality are  Plasmodium falciparum  and  P. vivax. One issue, which further compounds treatment of these pathogens, is one of drug resistance. Drug resistance often emerges from key mutations selected for by inadequate treatment regimes and has shown to be able to spread globally, further compounding the development of newer and more effective drug treatment programs, such as those from the World Health Organisation (WHO). Here we review the historical usage of anti-malarial drugs, the development of resistance in Africa and Asia, mechanisms of drug action and resistance, and the effects of resistance on WHO policy. 

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The authors declare that there are no conflicts of interest present.